Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1436044..1436559 Replicon chromosome
Accession NZ_CP043842
Organism Micrococcus luteus strain NCCP 16831

Toxin (Protein)


Gene name relE Uniprot ID A0A4Y1LR91
Locus tag F1718_RS06535 Protein ID WP_041103932.1
Coordinates 1436044..1436298 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag F1718_RS06540 Protein ID WP_036340860.1
Coordinates 1436299..1436559 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1718_RS06505 1431163..1432098 - 936 WP_158183888.1 glycosyltransferase family 2 protein -
F1718_RS06510 1432265..1432993 + 729 WP_199244596.1 MSMEG_4193 family putative phosphomutase -
F1718_RS06515 1432974..1433981 - 1008 WP_158183889.1 IS481 family transposase -
F1718_RS06520 1434108..1434650 + 543 WP_113913759.1 DUF3090 domain-containing protein -
F1718_RS06525 1434650..1435432 + 783 WP_158183890.1 SCO1664 family protein -
F1718_RS06530 1435476..1436042 - 567 WP_041103934.1 mismatch-specific DNA-glycosylase -
F1718_RS06535 1436044..1436298 - 255 WP_041103932.1 Txe/YoeB family addiction module toxin Toxin
F1718_RS06540 1436299..1436559 - 261 WP_036340860.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F1718_RS06545 1436745..1438148 + 1404 WP_155932746.1 GntP family permease -
F1718_RS06550 1438178..1439332 + 1155 WP_155932744.1 glycerate kinase -
F1718_RS06555 1439762..1440276 - 515 Protein_1268 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1428227..1447162 18935


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9996.33 Da        Isoelectric Point: 7.3149

>T139346 WP_041103932.1 NZ_CP043842:c1436298-1436044 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T139346 NZ_CP043842:c1436298-1436044 [Micrococcus luteus]
GTGCGCCTCGTGTGGGACCGCTCGGCCTGGGAGGACTACACGCACTGGCAGACCACGGACCGCAAGGTCCTCAAGCGGAT
CAACACCCTCATCGACGCCGCCCTGCGTGATCCCTTCGACGGGATCGGCAAGCCCGAGCAGCTGAAGTACGGCGCGCCCG
GGGCATGGTCCCGACGCATCACGGAGGAGCACAGGCTCGTCTACCTCGTCGACGGCGAGGACCTGATCATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT139346 WP_036340860.1 NZ_CP043842:c1436559-1436299 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT139346 NZ_CP043842:c1436559-1436299 [Micrococcus luteus]
ATGTCCATCAGCGCCAGTGAAGCCCGCAAGACCCTGTTCCCGCTCATCGAGCGAGTGAATGCGGACCGCGACGCCGTAGA
GATCGTCTCCCGCAAGGGGAATGCCGTCCTCATGCCCGCGGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCCCCGGCCAACGCCCGCCGGCTGCTGGACGCCTACGAGCGCGCCCGCGCAGGGAGCGTCGAGGAGCACGCTCTGGAC
CGCATGGACGGGGACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1LR91

Antitoxin

Source ID Structure
AlphaFold DB A0A229HG25

References