Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 618139..618648 Replicon chromosome
Accession NZ_CP043841
Organism Staphylococcus epidermidis strain NCCP 16829

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag F1616_RS03055 Protein ID WP_001829980.1
Coordinates 618139..618348 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag F1616_RS03060 Protein ID WP_001829893.1
Coordinates 618355..618648 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1616_RS03035 613718..615073 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
F1616_RS03040 615085..616158 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
F1616_RS03045 616549..617760 + 1212 WP_002486299.1 rod shape-determining protein RodA -
F1616_RS03050 617859..617996 - 138 WP_001829949.1 hypothetical protein -
F1616_RS03055 618139..618348 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
F1616_RS03060 618355..618648 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
F1616_RS03065 618822..620306 + 1485 WP_002457116.1 cardiolipin synthase -
F1616_RS03070 620488..621141 + 654 WP_001829983.1 HD domain-containing protein -
F1616_RS03075 621247..622119 - 873 WP_002458703.1 membrane protein insertase YidC -
F1616_RS03080 622208..622846 - 639 WP_002505076.1 thiamine phosphate synthase -
F1616_RS03085 622852..623640 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T139345 WP_001829980.1 NZ_CP043841:c618348-618139 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T139345 NZ_CP058651:3427481-3427699 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT139345 WP_001829893.1 NZ_CP043841:c618648-618355 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT139345 NZ_CP058651:3427081-3427455 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References