Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 606934..607463 Replicon chromosome
Accession NZ_CP043841
Organism Staphylococcus epidermidis strain NCCP 16829

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag F1616_RS02995 Protein ID WP_001829891.1
Coordinates 606934..607296 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag F1616_RS03000 Protein ID WP_001829931.1
Coordinates 607293..607463 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1616_RS02975 603936..604706 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
F1616_RS02980 604681..605160 - 480 WP_001829903.1 anti-sigma B factor RsbW -
F1616_RS02985 605162..605488 - 327 WP_001829952.1 anti-sigma factor antagonist -
F1616_RS02990 605588..606589 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
F1616_RS02995 606934..607296 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F1616_RS03000 607293..607463 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
F1616_RS03005 607550..608698 - 1149 WP_002457107.1 alanine racemase -
F1616_RS03010 608765..609118 - 354 WP_002457108.1 holo-ACP synthase -
F1616_RS03015 609166..609675 - 510 WP_002457109.1 PH domain-containing protein -
F1616_RS03020 609662..611167 - 1506 WP_002457110.1 PH domain-containing protein -
F1616_RS03025 611160..611639 - 480 WP_010959254.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T139344 WP_001829891.1 NZ_CP043841:c607296-606934 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T139344 NZ_CP058651:2624228-2624335 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT139344 WP_001829931.1 NZ_CP043841:c607463-607293 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT139344 NZ_CP058651:c2624175-2624114 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References