Detailed information of TA system TA139342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2345150..2346128
• Replicon: chromosome
• Accession: NZ_CP043830
• Organism: Bacillus sp. BS98

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: K0FNW8
• Locus tag: F0362_RS12155
• Protein ID: WP_000155917.1
• Coordinates: 2345150..2345890 (+)
• Length: 247 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: J8KE32
• Locus tag: F0362_RS12160
• Protein ID: WP_000588713.1
• Coordinates: 2346003..2346128 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0362_RS12135	2340812..2341594	+	783	WP_098628224.1	class I SAM-dependent methyltransferase	-
F0362_RS12140	2341773..2343449	-	1677	WP_141770324.1	alpha-keto acid decarboxylase family protein	-
F0362_RS12145	2343576..2344058	+	483	WP_000191892.1	MarR family winged helix-turn-helix transcriptional regulator	-
F0362_RS12150	2344226..2344963	+	738	WP_000594132.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
F0362_RS12155	2345150..2345890	+	741	WP_000155917.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
F0362_RS12160	2346003..2346128	+	126	WP_000588713.1	hypothetical protein	Antitoxin
F0362_RS12165	2346204..2346380	+	177	WP_000808012.1	stage II sporulation protein SB	-
F0362_RS12170	2346429..2346817	-	389	Protein_2255	YxeA family protein	-
F0362_RS12175	2347061..2348530	+	1470	WP_000287565.1	beta-Ala-His dipeptidase	-
F0362_RS12180	2348841..2349650	+	810	WP_000678381.1	C39 family peptidase	-
F0362_RS12185	2349678..2350280	+	603	WP_097895978.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (10-244)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 247 a.a.
• Molecular weight: 28446.03 Da
• Isoelectric Point: 7.3946

>T139342 WP_000155917.1 NZ_CP043830:2345150-2345890 [Bacillus sp. BS98]
MTISNIRIGLFILAIVFVVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIS
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTNIIQNINPAAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAANELNTGFRGIRSQFSITIPIEHIEQLNEQKAVQVENVGIIPAKIMNDVFIVIDGKKNSLQDRDFENVYNLTIH
HSYFSK

Nucleotide

• Length: 741 bp

>T139342 NZ_CP058651:2331072-2332394 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4951.43 Da
• Isoelectric Point: 4.1079

>AT139342 WP_000588713.1 NZ_CP043830:2346003-2346128 [Bacillus sp. BS98]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEKLEEELKRK

Nucleotide

• Length: 126 bp

>AT139342 NZ_CP058651:2330806-2331072 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: K0FNW8

Antitoxin

• AlphaFold DB: J8KE32