Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 238295..238937 Replicon chromosome
Accession NZ_CP043830
Organism Bacillus sp. BS98

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag F0362_RS01370 Protein ID WP_000635963.1
Coordinates 238587..238937 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag F0362_RS01365 Protein ID WP_000004570.1
Coordinates 238295..238582 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0362_RS01340 233622..234584 + 963 WP_000961174.1 UV DNA damage repair endonuclease UvsE -
F0362_RS01345 234577..235149 - 573 WP_000908503.1 rhomboid family intramembrane serine protease -
F0362_RS01350 235242..235601 + 360 WP_000635048.1 holo-ACP synthase -
F0362_RS01355 235758..236708 + 951 WP_002037834.1 outer membrane lipoprotein carrier protein LolA -
F0362_RS01360 236826..237995 + 1170 WP_000390621.1 alanine racemase -
F0362_RS01365 238295..238582 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
F0362_RS01370 238587..238937 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
F0362_RS01375 239006..241174 + 2169 WP_000426215.1 RNA-binding transcriptional accessory protein -
F0362_RS01380 241233..241349 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
F0362_RS01385 241557..242024 + 468 WP_000544525.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T139341 WP_000635963.1 NZ_CP043830:238587-238937 [Bacillus sp. BS98]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T139341 NZ_CP058651:2000484-2000587 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT139341 WP_000004570.1 NZ_CP043830:238295-238582 [Bacillus sp. BS98]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT139341 NZ_CP058651:c2000625-2000354 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References