Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | chpSB/PRK09812-ChpS |
| Location | 4982939..4983534 | Replicon | chromosome |
| Accession | NZ_CP043825 | ||
| Organism | Escherichia coli strain RM8082 | ||
Toxin (Protein)
| Gene name | chpB | Uniprot ID | A0A3L3YDL1 |
| Locus tag | F1745_RS24715 | Protein ID | WP_000239576.1 |
| Coordinates | 4983184..4983534 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | chpS | Uniprot ID | U9Y2K1 |
| Locus tag | F1745_RS24710 | Protein ID | WP_001223208.1 |
| Coordinates | 4982939..4983190 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F1745_RS24655 (4978250) | 4978250..4978453 | - | 204 | WP_001036813.1 | hypothetical protein | - |
| F1745_RS24660 (4978465) | 4978465..4978764 | - | 300 | WP_238013854.1 | hypothetical protein | - |
| F1745_RS24665 (4978761) | 4978761..4979006 | - | 246 | WP_032082656.1 | helix-turn-helix domain-containing protein | - |
| F1745_RS24670 (4979003) | 4979003..4979206 | - | 204 | WP_047615943.1 | hypothetical protein | - |
| F1745_RS24675 (4979230) | 4979230..4979640 | - | 411 | WP_047615940.1 | hypothetical protein | - |
| F1745_RS24680 (4979734) | 4979734..4979847 | - | 114 | WP_001519659.1 | hypothetical protein | - |
| F1745_RS24685 (4979844) | 4979844..4980086 | - | 243 | WP_000514277.1 | DUF4754 family protein | - |
| F1745_RS24690 (4980365) | 4980365..4980715 | - | 351 | WP_089576159.1 | DUF4761 family protein | - |
| F1745_RS24695 (4980753) | 4980753..4981178 | - | 426 | WP_052318234.1 | Cox family DNA-binding protein | - |
| F1745_RS24700 (4981305) | 4981305..4981586 | + | 282 | WP_227454766.1 | helix-turn-helix transcriptional regulator | - |
| F1745_RS24705 (4981653) | 4981653..4982648 | + | 996 | WP_238013856.1 | tyrosine-type recombinase/integrase | - |
| F1745_RS24710 (4982939) | 4982939..4983190 | + | 252 | WP_001223208.1 | type II toxin-antitoxin system antitoxin ChpS | Antitoxin |
| F1745_RS24715 (4983184) | 4983184..4983534 | + | 351 | WP_000239576.1 | endoribonuclease toxin ChpB | Toxin |
| F1745_RS24720 (4983614) | 4983614..4984144 | - | 531 | WP_000055075.1 | inorganic diphosphatase | - |
| F1745_RS24725 (4984454) | 4984454..4985410 | + | 957 | WP_000265933.1 | galactofuranose ABC transporter substrate-binding protein YtfQ | - |
| F1745_RS24730 (4985550) | 4985550..4987052 | + | 1503 | WP_000205795.1 | sugar ABC transporter ATP-binding protein | - |
| F1745_RS24735 (4987066) | 4987066..4988088 | + | 1023 | WP_001296689.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4946202..4997172 | 50970 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12566.53 Da Isoelectric Point: 6.2232
>T139324 WP_000239576.1 NZ_CP043825:4983184-4983534 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPIRQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE
Download Length: 351 bp
>T139324 NZ_CP058644:c807084-806794 [Pseudomonas yamanorum]
ATGAGCGAATCCTTTACCCGTTTCGATGCAGCAAATTACCTCAAGACCCCCGAAGACATGGCCGCTTATCTTGACGCCTG
CTTCGAGGAAGATGCCGGCGACGGCCTGCTTATTCGCACAGCCCTGAACGATATCGCGCGAGCCCAAGGAATGACTCAAG
TCGCCCGCAATGCGGGACTTGGACGAGAAAGTCTCTACAAAGCCCTCTCCAGCACTGGCAATCCCGAGTTCGCGACTATC
ATGAAGGTCATGAAAGCCCTTGGCCTCAAGCTGCACGCCACGGCAATCTGA
ATGAGCGAATCCTTTACCCGTTTCGATGCAGCAAATTACCTCAAGACCCCCGAAGACATGGCCGCTTATCTTGACGCCTG
CTTCGAGGAAGATGCCGGCGACGGCCTGCTTATTCGCACAGCCCTGAACGATATCGCGCGAGCCCAAGGAATGACTCAAG
TCGCCCGCAATGCGGGACTTGGACGAGAAAGTCTCTACAAAGCCCTCTCCAGCACTGGCAATCCCGAGTTCGCGACTATC
ATGAAGGTCATGAAAGCCCTTGGCCTCAAGCTGCACGCCACGGCAATCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9271.58 Da Isoelectric Point: 4.4201
>AT139324 WP_001223208.1 NZ_CP043825:4982939-4983190 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW
Download Length: 252 bp
>AT139324 NZ_CP043825:4982939-4983190 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L3YDL1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LQ26 |