Detailed information of TA system TA139311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2765723..2766348
• Replicon: chromosome
• Accession: NZ_CP043825
• Organism: Escherichia coli strain RM8082

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F1745_RS13895
• Protein ID: WP_000911330.1
• Coordinates: 2765723..2766121 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U9XQV3
• Locus tag: F1745_RS13900
• Protein ID: WP_000450524.1
• Coordinates: 2766121..2766348 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1745_RS13875 (2761631)	2761631..2761831	+	201	WP_000383836.1	YpfN family protein	-
F1745_RS13880 (2761912)	2761912..2762610	-	699	WP_000679812.1	esterase	-
F1745_RS13885 (2762684)	2762684..2764698	-	2015	Protein_2722	tRNA cytosine(34) acetyltransferase TmcA	-
F1745_RS13890 (2764713)	2764713..2765576	-	864	WP_001267508.1	neutral zinc metallopeptidase	-
F1745_RS13895 (2765723)	2765723..2766121	-	399	WP_000911330.1	type II toxin-antitoxin system VapC family toxin	Toxin
F1745_RS13900 (2766121)	2766121..2766348	-	228	WP_000450524.1	toxin-antitoxin system antitoxin VapB	Antitoxin
F1745_RS13905 (2766502)	2766502..2767215	-	714	WP_001295467.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
F1745_RS13910 (2767428)	2767428..2768462	-	1035	WP_001358397.1	outer membrane protein assembly factor BamC	-
F1745_RS13915 (2768479)	2768479..2769357	-	879	WP_001295469.1	4-hydroxy-tetrahydrodipicolinate synthase	-
F1745_RS13920 (2769503)	2769503..2770075	+	573	WP_000176187.1	glycine cleavage system transcriptional repressor	-
F1745_RS13925 (2770075)	2770075..2770545	+	471	WP_001068682.1	thioredoxin-dependent thiol peroxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14894.25 Da
• Isoelectric Point: 9.2216

>T139311 WP_000911330.1 NZ_CP043825:c2766121-2765723 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Nucleotide

• Length: 399 bp

>T139311 NZ_CP058624:2388322-2388726 [Treponema denticola]
ATGTATTTGCTAGATACAAATATCTGTATTTTCCTCATAAAGAATAAAAATCTATATTTAAAGAAAAAAATATTTAACTG
TAAAAAAGAAGAATTATTTCTTTCTTCCATTACAATTGCTGAGTTGGAGTATGGTGTTTCAAAAAGTCAATTTAGAGAAA
AGAATCGCCATGCTCTTCTGAATTTTTGTTCCGATTTTACTAATATAATAGATTTTACGACAGAAGATACAGAAACATAC
GGAATGATTAGAGCTTATCTTGAAAATAAAGGGGTTCCGATTGGACCTTTTGATACACAGATTGCTGCTCAAGGTTTAGC
AAGAAATCTTACTGTGGTTACAAATAATATAAGAGAATTTTCCAGAATACCTGGACTAAAAGTCGAAGACTGGACAAAAG
AATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8498.61 Da
• Isoelectric Point: 4.3867

>AT139311 WP_000450524.1 NZ_CP043825:c2766348-2766121 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Nucleotide

• Length: 228 bp

>AT139311 NZ_CP058624:2388092-2388322 [Treponema denticola]
ATGATTTGTACAAAAGTATTCACAAGTGGAAATAGTCAGGCTGTAAGAATACCTAAAGAATTTCATATTGATTTTTCTGA
ATTATTAATCAAAAAAATCGGTTCATCAATAATCCTAACACCAAAAGAAAGCAATTGGGAAAATCTTGAGAGAAGTCTTT
CTGAGTTTTCTGATGATTTCATGACAGAAGGAAGAAGTCAACCGGCAATGCAAGAAAGGGAAGTTTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829CM33