Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2227130..2227603 Replicon chromosome
Accession NZ_CP043825
Organism Escherichia coli strain RM8082

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag F1745_RS11415 Protein ID WP_032214969.1
Coordinates 2227322..2227603 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag F1745_RS11410 Protein ID WP_032214970.1
Coordinates 2227130..2227318 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1745_RS11365 (2222211) 2222211..2222522 - 312 WP_047088262.1 hypothetical protein -
F1745_RS11370 (2222715) 2222715..2223011 - 297 WP_047088264.1 DUF4406 domain-containing protein -
F1745_RS11375 (2223008) 2223008..2223262 - 255 WP_077756511.1 DNA-binding protein -
F1745_RS11380 (2223319) 2223319..2224080 - 762 WP_032214976.1 DUF1627 domain-containing protein -
F1745_RS11385 (2224103) 2224103..2224849 - 747 WP_032214975.1 ATP-binding protein -
F1745_RS11390 (2224856) 2224856..2225821 - 966 WP_032214974.1 phage O protein family -
F1745_RS11395 (2225802) 2225802..2226323 - 522 WP_032214973.1 toxin YdaT family protein -
F1745_RS11400 (2226307) 2226307..2226585 - 279 WP_032214972.1 YdaS family helix-turn-helix protein -
F1745_RS11405 (2226702) 2226702..2227100 + 399 WP_032214971.1 helix-turn-helix domain-containing protein -
F1745_RS11410 (2227130) 2227130..2227318 + 189 WP_032214970.1 hypothetical protein Antitoxin
F1745_RS11415 (2227322) 2227322..2227603 + 282 WP_032214969.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1745_RS11420 (2227890) 2227890..2228045 + 156 WP_047088278.1 DUF1391 family protein -
F1745_RS27630 (2228047) 2228047..2228175 + 129 WP_077756509.1 protein YdfB -
F1745_RS11425 (2228205) 2228205..2228423 + 219 WP_001171946.1 protein YdfC -
F1745_RS11430 (2228446) 2228446..2228775 + 330 WP_032214967.1 hypothetical protein -
F1745_RS11435 (2228744) 2228744..2229019 - 276 WP_000102679.1 hypothetical protein -
F1745_RS11440 (2229581) 2229581..2229769 + 189 WP_032214966.1 cell division inhibition protein DicB -
F1745_RS11445 (2229766) 2229766..2229957 + 192 WP_001070255.1 DUF1482 family protein -
F1745_RS11450 (2230051) 2230051..2232492 + 2442 WP_032214965.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stxB / stxA 2184751..2245322 60571


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10742.45 Da        Isoelectric Point: 6.7152

>T139309 WP_032214969.1 NZ_CP043825:2227322-2227603 [Escherichia coli]
MLPVLWLESADADLDDITSYIARFDIDAAERLWKRLRACVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVAASSIE
IVSIVHARRQFPR

Download         Length: 282 bp

>T139309 NZ_CP058624:c1495821-1495519 [Treponema denticola]
ATGGTTCGAGATTGTTTTGAATGGGATACTACTAAAAATGATAATAATAAAAGGAAACATGGTGTTTCTTTTGAAGATGC
TATCTTAATTTTTGATGATCCCTATTTGCTTGAAAAATATGATTCAAAACATTCCGAATATGAAGATAGATTTTTAGCAA
TTGGTTCTATATGTGGTCTGGTGCTTATAGCTGTAGCATATACGGATAGGGCCGGTATAACAAGGATTATATCTGCAAGA
TCTGCAACTAAGGCAGAAAAGGAATTATACTATGATAAAATCAATGAATATTACGGAAGCTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7232.20 Da        Isoelectric Point: 7.0135

>AT139309 WP_032214970.1 NZ_CP043825:2227130-2227318 [Escherichia coli]
MNTALSPMVSEFETIEQENSYNEWLRAKVAASLADPRPAIPHDEVERRMAERFAKIRKERSK

Download         Length: 189 bp

>AT139309 NZ_CP058624:c1495538-1495266 [Treponema denticola]
ATGAATATTACGGAAGCTAAGAAAAACTTAACAAAAGAAAAAATTGAAGAATTAAAAGCTTTAAATGACAGACCTATAGA
TACTTCAGACATTCCTGAACTAACAAAAGCTGATTTTTTGGAAATGTACCGCCCTATTAAAAAGCCCTTATCAATAAGAC
TTGATTCCGATATTATTGCTTGGCTTAAATCATACGGAAAAGGTTACCAAAGCCGTATAAATACTATTTTAAGACAAGCT
ATGAATACCGATAAAAAAGCAAATGTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References