Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4949614..4950209 Replicon chromosome
Accession NZ_CP043821
Organism Escherichia coli strain RM10740

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag F1748_RS24310 Protein ID WP_000239579.1
Coordinates 4949859..4950209 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag F1748_RS24305 Protein ID WP_001223208.1
Coordinates 4949614..4949865 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1748_RS24295 (4945278) 4945278..4949057 + 3780 WP_089515977.1 autotransporter assembly complex protein TamB -
F1748_RS24300 (4949060) 4949060..4949401 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
F1748_RS24305 (4949614) 4949614..4949865 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
F1748_RS24310 (4949859) 4949859..4950209 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
F1748_RS24315 (4950289) 4950289..4950819 - 531 WP_000055072.1 inorganic diphosphatase -
F1748_RS24320 (4951129) 4951129..4952085 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
F1748_RS24325 (4952395) 4952395..4953897 + 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
F1748_RS24330 (4953911) 4953911..4954933 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T139284 WP_000239579.1 NZ_CP043821:4949859-4950209 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T139284 NZ_CP058615:c1039255-1039160 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT139284 WP_001223208.1 NZ_CP043821:4949614-4949865 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT139284 NZ_CP058615:1039073-1039132 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References