Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4058673..4059259 Replicon chromosome
Accession NZ_CP043821
Organism Escherichia coli strain RM10740

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag F1748_RS20195 Protein ID WP_042014162.1
Coordinates 4059029..4059259 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F1748_RS20190 Protein ID WP_238005030.1
Coordinates 4058673..4059032 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1748_RS20165 (4054805) 4054805..4055749 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
F1748_RS20170 (4055746) 4055746..4056579 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
F1748_RS20175 (4056579) 4056579..4057343 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
F1748_RS20180 (4057340) 4057340..4058146 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
F1748_RS20185 (4058152) 4058152..4058553 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
F1748_RS20190 (4058673) 4058673..4059032 - 360 WP_238005030.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1748_RS20195 (4059029) 4059029..4059259 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
F1748_RS20200 (4059363) 4059363..4060487 - 1125 WP_001314210.1 ABC transporter permease -
F1748_RS20205 (4060487) 4060487..4063222 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T139281 WP_042014162.1 NZ_CP043821:c4059259-4059029 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T139281 NZ_CP043821:c4059259-4059029 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13392.24 Da        Isoelectric Point: 5.1987

>AT139281 WP_238005030.1 NZ_CP043821:c4059032-4058673 [Escherichia coli]
MIKLKTSNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT139281 NZ_CP058615:809642-809812 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure

References