Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3172042..3172877 Replicon chromosome
Accession NZ_CP043821
Organism Escherichia coli strain RM10740

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7S8K0
Locus tag F1748_RS15820 Protein ID WP_000854723.1
Coordinates 3172500..3172877 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7S6L8
Locus tag F1748_RS15815 Protein ID WP_001285573.1
Coordinates 3172042..3172410 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1748_RS15795 (3169758) 3169758..3170576 + 819 WP_238005015.1 DUF932 domain-containing protein -
F1748_RS15800 (3170668) 3170668..3171162 + 495 WP_032167345.1 antirestriction protein -
F1748_RS15805 (3171178) 3171178..3171654 + 477 WP_001360063.1 RadC family protein -
F1748_RS15810 (3171741) 3171741..3171962 + 222 WP_000692176.1 DUF987 domain-containing protein -
F1748_RS15815 (3172042) 3172042..3172410 + 369 WP_001285573.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F1748_RS15820 (3172500) 3172500..3172877 + 378 WP_000854723.1 TA system toxin CbtA family protein Toxin
F1748_RS15825 (3172874) 3172874..3173362 + 489 WP_000761669.1 DUF5983 family protein -
F1748_RS15830 (3173382) 3173382..3173579 + 198 WP_000445281.1 DUF957 domain-containing protein -
F1748_RS15835 (3173664) 3173664..3174509 + 846 WP_001280431.1 DUF4942 domain-containing protein -
F1748_RS15845 (3175244) 3175244..3177496 + 2253 Protein_3100 alpha-amylase family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3150914..3186890 35976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14145.23 Da        Isoelectric Point: 8.2904

>T139276 WP_000854723.1 NZ_CP043821:3172500-3172877 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRTRRATGLMARDNYRTVNNIILGKHPGAKQ

Download         Length: 378 bp

>T139276 NZ_CP043821:3172500-3172877 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGACCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTATCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13585.33 Da        Isoelectric Point: 6.3159

>AT139276 WP_001285573.1 NZ_CP043821:3172042-3172410 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCSVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT139276 NZ_CP058615:406284-406541 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References