139275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2853580..2854205 Replicon chromosome
Accession NZ_CP043821
Organism Escherichia coli strain RM10740

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag F1748_RS14160 Protein ID WP_000911329.1
Coordinates 2853580..2853978 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag F1748_RS14165 Protein ID WP_000450524.1
Coordinates 2853978..2854205 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1748_RS14140 (2849458) 2849458..2849658 + 201 WP_000383836.1 YpfN family protein -
F1748_RS14145 (2849768) 2849768..2850466 - 699 WP_238004996.1 esterase -
F1748_RS14150 (2850540) 2850540..2852555 - 2016 WP_000829332.1 tRNA cytosine(34) acetyltransferase TmcA -
F1748_RS14155 (2852570) 2852570..2853433 - 864 WP_001267507.1 neutral zinc metallopeptidase -
F1748_RS14160 (2853580) 2853580..2853978 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
F1748_RS14165 (2853978) 2853978..2854205 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
F1748_RS14170 (2854361) 2854361..2855074 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
F1748_RS14175 (2855287) 2855287..2856321 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
F1748_RS14180 (2856338) 2856338..2857216 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
F1748_RS14185 (2857362) 2857362..2857934 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
F1748_RS14190 (2857934) 2857934..2858404 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T139275 WP_000911329.1 NZ_CP043821:c2853978-2853580 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T139275 NZ_CP058613:c2276810-2276559 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATCGAACAATCAGTTATTAGTGCTAGCGCGTATAACGGCAATGACACAGAGGGATTATTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGAATTATGGCAGGTCAAGTTGTTTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT139275 WP_000450524.1 NZ_CP043821:c2854205-2853978 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT139275 NZ_CP058613:c2276569-2276396 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References