Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 5168290..5168854 Replicon chromosome
Accession NZ_CP043820
Organism Achromobacter xylosoxidans strain AX1

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag F0U64_RS23340 Protein ID WP_020926667.1
Coordinates 5168290..5168571 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag F0U64_RS23345 Protein ID WP_020926666.1
Coordinates 5168558..5168854 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0U64_RS23315 5163322..5163825 - 504 WP_006386642.1 flavin reductase family protein -
F0U64_RS23320 5163849..5164862 - 1014 WP_024070172.1 LLM class flavin-dependent oxidoreductase -
F0U64_RS23325 5164984..5165817 + 834 WP_024070173.1 IclR family transcriptional regulator -
F0U64_RS23330 5166052..5167107 + 1056 WP_054442897.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
F0U64_RS23335 5167104..5168240 + 1137 WP_054439645.1 tRNA guanosine(34) transglycosylase Tgt -
F0U64_RS23340 5168290..5168571 - 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0U64_RS23345 5168558..5168854 - 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F0U64_RS23350 5169227..5169571 + 345 WP_006386647.1 preprotein translocase subunit YajC -
F0U64_RS23355 5169687..5171567 + 1881 WP_006386648.1 protein translocase subunit SecD -
F0U64_RS23360 5171619..5172554 + 936 WP_006386649.1 protein translocase subunit SecF -
F0U64_RS23365 5172724..5173092 + 369 WP_006386650.1 type II toxin-antitoxin system RelE/ParE family toxin -
F0U64_RS23370 5173089..5173400 + 312 WP_006386651.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T139256 WP_020926667.1 NZ_CP043820:c5168571-5168290 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T139256 NZ_CP058596:3759132-3759350 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT139256 WP_020926666.1 NZ_CP043820:c5168854-5168558 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT139256 NZ_CP058596:3758732-3759106 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References