Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 4183940..4184481 Replicon chromosome
Accession NZ_CP043820
Organism Achromobacter xylosoxidans strain AX1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F0U64_RS18830 Protein ID WP_026384571.1
Coordinates 4183940..4184215 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F0U64_RS18835 Protein ID WP_149895281.1
Coordinates 4184215..4184481 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0U64_RS18810 4179892..4180815 + 924 WP_006385014.1 ABC transporter permease -
F0U64_RS18815 4180821..4181687 + 867 WP_006385013.1 ABC transporter permease -
F0U64_RS18820 4181745..4183484 + 1740 WP_054507206.1 peptidase M14 -
F0U64_RS18825 4183497..4183934 + 438 WP_006385010.1 acetyltransferase -
F0U64_RS18830 4183940..4184215 - 276 WP_026384571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0U64_RS18835 4184215..4184481 - 267 WP_149895281.1 ribbon-helix-helix domain-containing protein Antitoxin
F0U64_RS18840 4184728..4185255 + 528 WP_024069591.1 sigma-70 family RNA polymerase sigma factor -
F0U64_RS18845 4185341..4186297 + 957 WP_054498804.1 FecR domain-containing protein -
F0U64_RS18850 4186557..4188983 + 2427 WP_070543066.1 TonB-dependent receptor -
F0U64_RS18855 4189036..4189242 - 207 WP_006385007.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10710.42 Da        Isoelectric Point: 10.4170

>T139255 WP_026384571.1 NZ_CP043820:c4184215-4183940 [Achromobacter xylosoxidans]
MEMKWTSKALSDLARLHEFLAAVNRPAAVRAVQALVKASSVLPTNSRIGEQLFQFEPREVRRILVGEYEIRYEIRDSIIY
VLRLWHTRENR

Download         Length: 276 bp

>T139255 NZ_CP058596:c3038790-3038410 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9729.07 Da        Isoelectric Point: 4.5720

>AT139255 WP_149895281.1 NZ_CP043820:c4184481-4184215 [Achromobacter xylosoxidans]
MSPATKVLTAHVPLPLAEKVDQMAVRLDRSRGWIVKQALSAWIAQEEERDKLTEQALADVDAGRIVDDQAVQTWAESLGS
DQPLPLPR

Download         Length: 267 bp

>AT139255 NZ_CP058596:c3039211-3038837 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References