Detailed information of TA system TA139254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2491622..2492302
• Replicon: chromosome
• Accession: NZ_CP043820
• Organism: Achromobacter xylosoxidans strain AX1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: F0U64_RS11295
• Protein ID: WP_006386381.1
• Coordinates: 2491622..2491807 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: F0U64_RS11300
• Protein ID: WP_006386380.1
• Coordinates: 2491883..2492302 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0U64_RS11285	2487758..2489161	+	1404	WP_024068590.1	dihydrolipoyl dehydrogenase	-
F0U64_RS11290	2489336..2491375	-	2040	WP_149895018.1	pyruvate, phosphate dikinase	-
F0U64_RS11295	2491622..2491807	+	186	WP_006386381.1	type II toxin-antitoxin system HicA family toxin	Toxin
F0U64_RS11300	2491883..2492302	+	420	WP_006386380.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F0U64_RS11305	2492393..2493811	-	1419	WP_006386379.1	argininosuccinate lyase	-
F0U64_RS11310	2494021..2495352	+	1332	WP_049053945.1	mechanosensitive ion channel	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-94)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7058.16 Da
• Isoelectric Point: 10.6654

>T139254 WP_006386381.1 NZ_CP043820:2491622-2491807 [Achromobacter xylosoxidans]
MKYSEFKKWLERQGAVFVAHRSGSSHFRVTLNGATTIFPYHGSKEMGKHLEHEIKKQLGLK

Nucleotide

• Length: 186 bp

>T139254 NZ_CP058596:2829400-2829507 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15506.81 Da
• Isoelectric Point: 4.9597

>AT139254 WP_006386380.1 NZ_CP043820:2491883-2492302 [Achromobacter xylosoxidans]
MLTYPFTLTLDSNRTWLVRFPDIPEALTVGDDEQEAAINAREALEAALEIYFDARRPIPLPSPVSAGQASVTLPALITSK
VFLSNEMIQQGVRKAELARRMGVHMPQVDRLLDVRHASRIEQVESALEQLGRRLEVSLA

Nucleotide

• Length: 420 bp

>AT139254 NZ_CP058596:c2829344-2829283 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTCT