Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1133014..1133587 Replicon chromosome
Accession NZ_CP043820
Organism Achromobacter xylosoxidans strain AX1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F0U64_RS05120 Protein ID WP_054439446.1
Coordinates 1133210..1133587 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag F0U64_RS05115 Protein ID WP_054471260.1
Coordinates 1133014..1133223 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0U64_RS05095 1128420..1129208 - 789 WP_049054627.1 helix-turn-helix transcriptional regulator -
F0U64_RS05100 1129307..1130233 + 927 WP_020924995.1 DMT family transporter -
F0U64_RS05105 1130246..1131064 - 819 WP_054439448.1 AAC(3) family N-acetyltransferase -
F0U64_RS05110 1131216..1132889 + 1674 WP_024067854.1 energy-dependent translational throttle protein EttA -
F0U64_RS05115 1133014..1133223 + 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
F0U64_RS05120 1133210..1133587 + 378 WP_054439446.1 type II toxin-antitoxin system VapC family toxin Toxin
F0U64_RS05125 1133655..1134188 + 534 WP_070542799.1 isochorismatase family protein -
F0U64_RS05130 1134379..1134603 + 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
F0U64_RS05135 1134733..1134990 - 258 WP_006388977.1 cell division topological specificity factor MinE -
F0U64_RS05140 1134994..1135809 - 816 WP_006388978.1 septum site-determining protein MinD -
F0U64_RS05145 1135998..1136915 - 918 WP_024067857.1 septum site-determining protein MinC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13906.15 Da        Isoelectric Point: 6.3738

>T139253 WP_054439446.1 NZ_CP043820:1133210-1133587 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPYLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGAMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTRDKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

>T139253 NZ_CP058596:2591156-2591434 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGTAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT139253 WP_054471260.1 NZ_CP043820:1133014-1133223 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp

>AT139253 NZ_CP058596:2591434-2591718 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCTACGGCAAGTCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCTGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCAGAA
AAAACAGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References