Detailed information of TA system TA139252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 196355..196909
• Replicon: chromosome
• Accession: NZ_CP043820
• Organism: Achromobacter xylosoxidans strain AX1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0D6FFH4
• Locus tag: F0U64_RS00840
• Protein ID: WP_006386989.1
• Coordinates: 196631..196909 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F0U64_RS00835
• Protein ID: WP_006386988.1
• Coordinates: 196355..196561 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0U64_RS00820	192998..193975	-	978	WP_006386985.1	tripartite tricarboxylate transporter substrate binding protein	-
F0U64_RS00825	194167..194817	-	651	WP_149894723.1	hypothetical protein	-
F0U64_RS00830	194816..196261	+	1446	WP_035182700.1	RNA polymerase factor sigma-54	-
F0U64_RS00835	196355..196561	+	207	WP_006386988.1	hypothetical protein	Antitoxin
F0U64_RS00840	196631..196909	+	279	WP_006386989.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F0U64_RS00845	197088..197387	+	300	WP_006386990.1	(2Fe-2S)-binding protein	-
F0U64_RS00850	197357..198277	-	921	WP_006386991.1	LysR family transcriptional regulator	-
F0U64_RS00855	198390..199304	+	915	WP_054498188.1	DMT family transporter	-
F0U64_RS00860	199729..200205	+	477	WP_006386993.1	bacterioferritin	-
F0U64_RS00865	200291..200989	-	699	WP_149894724.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10370.91 Da
• Isoelectric Point: 9.0854

>T139252 WP_006386989.1 NZ_CP043820:196631-196909 [Achromobacter xylosoxidans]
MLDVSWLQTAADDLAGIISYIAERSPQAARDLRQRIDNAVLSLARHPCRYRAGRVSGTRECVVHPNYVVVYRVTALAIEV
VNIVHARREYPP

Nucleotide

• Length: 279 bp

>T139252 NZ_CP058596:2553573-2554895 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGATAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGAATTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7681.57 Da
• Isoelectric Point: 4.5026

>AT139252 WP_006386988.1 NZ_CP043820:196355-196561 [Achromobacter xylosoxidans]
MGPIPSSILSEVETEEQAVSYDRWFRAKVQASLDDPRPAVSHQRVMARIDAIIETACRRQLDPQDGEN

Nucleotide

• Length: 207 bp

>AT139252 NZ_CP043820:196355-196561 [Achromobacter xylosoxidans]
ATGGGCCCAATCCCTTCCTCCATCCTCTCGGAAGTCGAGACCGAAGAACAGGCGGTCAGCTACGACCGCTGGTTCCGCGC
GAAGGTGCAAGCCAGCCTGGACGATCCGCGTCCCGCCGTTTCGCATCAAAGGGTGATGGCCCGCATCGATGCCATTATCG
AAACGGCGTGCCGTCGTCAGCTGGATCCGCAAGACGGAGAAAACTGA

Structures

Toxin

• AlphaFold DB: A0A0D6FFH4