Detailed information of TA system TA139250

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1654952..1655637
• Replicon: chromosome
• Accession: NZ_CP043816
• Organism: Neisseria gonorrhoeae strain NG251

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: F0T11_RS08540
• Protein ID: WP_003689143.1
• Coordinates: 1655455..1655637 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: F0T11_RS08535
• Protein ID: WP_003691454.1
• Coordinates: 1654952..1655353 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0T11_RS08480	1649999..1650214	-	216	WP_003691538.1	hypothetical protein	-
F0T11_RS08485	1650266..1650757	-	492	WP_003691537.1	siphovirus Gp157 family protein	-
F0T11_RS08490	1650754..1650936	-	183	WP_003691535.1	hypothetical protein	-
F0T11_RS08495	1651076..1651762	-	687	WP_082278088.1	hypothetical protein	-
F0T11_RS08500	1651831..1651992	-	162	WP_003693867.1	hypothetical protein	-
F0T11_RS08505	1651989..1652264	-	276	WP_047918704.1	hypothetical protein	-
F0T11_RS08510	1652417..1652749	-	333	WP_003695500.1	hypothetical protein	-
F0T11_RS08515	1652890..1653177	-	288	WP_050157611.1	hypothetical protein	-
F0T11_RS08520	1653174..1653650	-	477	WP_002255718.1	hypothetical protein	-
F0T11_RS08525	1653683..1653883	-	201	WP_003692842.1	hypothetical protein	-
F0T11_RS08530	1654072..1654854	+	783	WP_003689146.1	hypothetical protein	-
F0T11_RS08535	1654952..1655353	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F0T11_RS08540	1655455..1655637	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
F0T11_RS08545	1655807..1656625	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
F0T11_RS08550	1656622..1657320	-	699	WP_003689139.1	hypothetical protein	-
F0T11_RS08555	1657559..1658269	-	711	WP_025455899.1	helix-turn-helix transcriptional regulator	-
F0T11_RS08560	1658385..1658573	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
F0T11_RS08565	1658653..1658808	+	156	WP_003689578.1	hypothetical protein	-
F0T11_RS08570	1658785..1658973	-	189	WP_050157615.1	hypothetical protein	-
F0T11_RS08575	1659146..1659373	+	228	WP_003693879.1	helix-turn-helix domain-containing protein	-
F0T11_RS08580	1659491..1660555	+	1065	WP_003689134.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1639770..1674031	34261

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T139250 WP_003689143.1 NZ_CP043816:c1655637-1655455 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T139250 NZ_CP043816:c1655637-1655455 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT139250 WP_003691454.1 NZ_CP043816:c1655353-1654952 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT139250 NZ_CP043816:c1655353-1654952 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2