Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 675919..676574 Replicon chromosome
Accession NZ_CP043816
Organism Neisseria gonorrhoeae strain NG251

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag F0T11_RS03635 Protein ID WP_003691083.1
Coordinates 676155..676574 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag F0T11_RS03630 Protein ID WP_003688410.1
Coordinates 675919..676155 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0T11_RS03595 671053..671340 + 288 WP_003688407.1 hypothetical protein -
F0T11_RS03600 671412..672578 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
F0T11_RS03605 672589..673479 + 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
F0T11_RS03610 673862..674248 - 387 Protein_703 IS110 family transposase -
F0T11_RS03615 674460..674888 + 429 WP_003701165.1 helix-turn-helix domain-containing protein -
F0T11_RS03620 674893..675471 + 579 WP_003688041.1 IS3 family transposase -
F0T11_RS03625 675516..675713 + 198 WP_033910354.1 IS3 family transposase -
F0T11_RS03630 675919..676155 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
F0T11_RS03635 676155..676574 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
F0T11_RS03640 676723..678177 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
F0T11_RS03645 678174..678875 - 702 WP_003688414.1 lactate utilization protein C -
F0T11_RS03650 678872..679651 - 780 WP_003701284.1 (Fe-S)-binding protein -
F0T11_RS03655 679799..681340 + 1542 WP_003701286.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T139249 WP_003691083.1 NZ_CP043816:676155-676574 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T139249 NZ_CP058596:1960853-1961107 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT139249 WP_003688410.1 NZ_CP043816:675919-676155 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT139249 NZ_CP058596:1960605-1960856 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References