Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1201..1664 Replicon plasmid p3
Accession NZ_CP043815
Organism Neisseria gonorrhoeae strain NG290

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag F0T12_RS11900 Protein ID WP_003690225.1
Coordinates 1386..1664 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag F0T12_RS11895 Protein ID WP_003690223.1
Coordinates 1201..1386 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0T12_RS11885 714..956 + 243 WP_003690220.1 HTH domain-containing protein -
F0T12_RS11890 953..1198 + 246 WP_003690221.1 hypothetical protein -
F0T12_RS11895 1201..1386 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
F0T12_RS11900 1386..1664 + 279 WP_003690225.1 endoribonuclease VapD Toxin
F0T12_RS11905 1642..1911 - 270 WP_003692166.1 hypothetical protein -
F0T12_RS11910 1943..2584 - 642 WP_003690229.1 Cryptic plasmid protein B -
F0T12_RS11915 2668..3297 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
F0T12_RS11920 3282..3473 - 192 WP_003690218.1 plasmid mobilization relaxosome protein MobC -
F0T12_RS11925 3741..3965 + 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T139248 WP_003690225.1 NZ_CP043815:1386-1664 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T139248 NZ_CP058596:1960605-1960856 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT139248 WP_003690223.1 NZ_CP043815:1201-1386 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT139248 NZ_CP058596:1960853-1961107 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References