Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1658671..1659356 | Replicon | chromosome |
| Accession | NZ_CP043812 | ||
| Organism | Neisseria gonorrhoeae strain NG290 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | Q5F6D1 |
| Locus tag | F0T12_RS08555 | Protein ID | WP_003689143.1 |
| Coordinates | 1659174..1659356 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | Q5F6D2 |
| Locus tag | F0T12_RS08550 | Protein ID | WP_003691454.1 |
| Coordinates | 1658671..1659072 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F0T12_RS08495 | 1653718..1653933 | - | 216 | WP_003691538.1 | hypothetical protein | - |
| F0T12_RS08500 | 1653985..1654476 | - | 492 | WP_003691537.1 | siphovirus Gp157 family protein | - |
| F0T12_RS08505 | 1654473..1654655 | - | 183 | WP_003691535.1 | hypothetical protein | - |
| F0T12_RS08510 | 1654795..1655481 | - | 687 | WP_082278088.1 | hypothetical protein | - |
| F0T12_RS08515 | 1655550..1655711 | - | 162 | WP_003693867.1 | hypothetical protein | - |
| F0T12_RS08520 | 1655708..1655983 | - | 276 | WP_047918704.1 | hypothetical protein | - |
| F0T12_RS08525 | 1656136..1656468 | - | 333 | WP_003695500.1 | hypothetical protein | - |
| F0T12_RS08530 | 1656609..1656896 | - | 288 | WP_050157611.1 | hypothetical protein | - |
| F0T12_RS08535 | 1656893..1657369 | - | 477 | WP_002255718.1 | hypothetical protein | - |
| F0T12_RS08540 | 1657402..1657602 | - | 201 | WP_003692842.1 | hypothetical protein | - |
| F0T12_RS08545 | 1657791..1658573 | + | 783 | WP_003689146.1 | hypothetical protein | - |
| F0T12_RS08550 | 1658671..1659072 | - | 402 | WP_003691454.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| F0T12_RS08555 | 1659174..1659356 | - | 183 | WP_003689143.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| F0T12_RS08560 | 1659526..1660344 | - | 819 | WP_012503752.1 | DUF3037 domain-containing protein | - |
| F0T12_RS08565 | 1660341..1661039 | - | 699 | WP_003689139.1 | hypothetical protein | - |
| F0T12_RS08570 | 1661278..1661988 | - | 711 | WP_025455899.1 | helix-turn-helix transcriptional regulator | - |
| F0T12_RS08575 | 1662104..1662292 | + | 189 | WP_003689136.1 | helix-turn-helix domain-containing protein | - |
| F0T12_RS08580 | 1662372..1662527 | + | 156 | WP_003689578.1 | hypothetical protein | - |
| F0T12_RS08585 | 1662504..1662692 | - | 189 | WP_050157615.1 | hypothetical protein | - |
| F0T12_RS08590 | 1662865..1663092 | + | 228 | WP_003693879.1 | helix-turn-helix domain-containing protein | - |
| F0T12_RS08595 | 1663210..1664274 | + | 1065 | WP_003689134.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1643489..1677750 | 34261 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6687.77 Da Isoelectric Point: 10.7235
>T139246 WP_003689143.1 NZ_CP043812:c1659356-1659174 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK
Download Length: 183 bp
>T139246 NZ_CP058596:1051878-1052285 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14634.43 Da Isoelectric Point: 4.5457
>AT139246 WP_003691454.1 NZ_CP043812:c1659072-1658671 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA
Download Length: 402 bp
>AT139246 NZ_CP058596:1051631-1051897 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTTTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|