Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 947953..948608 Replicon chromosome
Accession NZ_CP043812
Organism Neisseria gonorrhoeae strain NG290

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag F0T12_RS04840 Protein ID WP_003691083.1
Coordinates 947953..948372 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag F0T12_RS04845 Protein ID WP_003688410.1
Coordinates 948372..948608 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0T12_RS04820 943187..944728 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
F0T12_RS04825 944876..945655 + 780 WP_003701284.1 (Fe-S)-binding protein -
F0T12_RS04830 945652..946353 + 702 WP_003688414.1 lactate utilization protein C -
F0T12_RS04835 946350..947804 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
F0T12_RS04840 947953..948372 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
F0T12_RS04845 948372..948608 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
F0T12_RS04850 948814..949011 - 198 WP_033910354.1 IS3 family transposase -
F0T12_RS04855 949056..949634 - 579 WP_003688041.1 IS3 family transposase -
F0T12_RS04860 949639..950067 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
F0T12_RS04865 950279..950665 + 387 Protein_960 IS110 family transposase -
F0T12_RS04870 951048..951938 - 891 WP_003688409.1 succinate--CoA ligase subunit alpha -
F0T12_RS04875 951949..953115 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
F0T12_RS04880 953187..953474 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T139245 WP_003691083.1 NZ_CP043812:c948372-947953 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T139245 NZ_CP058596:c892926-892552 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT139245 WP_003688410.1 NZ_CP043812:c948608-948372 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT139245 NZ_CP058596:c893384-893016 [Escherichia coli]
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References