Detailed information of TA system TA139244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 3096716..3097365
• Replicon: chromosome
• Accession: NZ_CP043808
• Organism: Serinicoccus marinus DSM 15273

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FU792_RS14935
• Protein ID: WP_022925783.1
• Coordinates: 3096967..3097365 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FU792_RS14930
• Protein ID: WP_022925782.1
• Coordinates: 3096716..3096970 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU792_RS14905	3091993..3092496	-	504	WP_022925777.1	hypothetical protein	-
FU792_RS14910	3092506..3094464	-	1959	WP_022925778.1	DNA/RNA non-specific endonuclease	-
FU792_RS14915	3094464..3094781	-	318	WP_022925779.1	hypothetical protein	-
FU792_RS14920	3094816..3095238	-	423	WP_022925780.1	hypothetical protein	-
FU792_RS14925	3095355..3096643	+	1289	Protein_2955	NupC/NupG family nucleoside CNT transporter	-
FU792_RS14930	3096716..3096970	+	255	WP_022925782.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FU792_RS14935	3096967..3097365	+	399	WP_022925783.1	type II toxin-antitoxin system VapC family toxin	Toxin
FU792_RS14940	3097391..3098379	+	989	Protein_2958	NAD(P)H-quinone oxidoreductase	-
FU792_RS14945	3099400..3100413	-	1014	WP_022925786.1	hypothetical protein	-
FU792_RS14950	3100437..3100949	-	513	WP_022925787.1	NUDIX hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14036.02 Da
• Isoelectric Point: 4.8486

>T139244 WP_022925783.1 NZ_CP043808:3096967-3097365 [Serinicoccus marinus DSM 15273]
VTIVLDTSAVAAVIFGEPDAETLLRVMQRAAGDLLMSAATSVEVGIVVETRQGREATQDLRLLLDRLGVDIAPLDAAQAS
IAVDAWRRFGKGRHPASLNLGDCFAYAAAQRRDAPLLFKGGDFAQTDVRSAL

Nucleotide

• Length: 399 bp

>T139244 NZ_CP058596:c675773-675309 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9129.24 Da
• Isoelectric Point: 4.5749

>AT139244 WP_022925782.1 NZ_CP043808:3096716-3096970 [Serinicoccus marinus DSM 15273]
MALNIKDAETDRLARELADATGESITVAARRAIEERLARVTALARAEKGTDELEGIIDRGRRRPVIDARTPEDIVGYDEA
GLPG

Nucleotide

• Length: 255 bp

>AT139244 NZ_CP058596:c676108-675773 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA