Detailed information of TA system TA139242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-mazE/VapC(toxin)
• Location: 2910416..2911192
• Replicon: chromosome
• Accession: NZ_CP043808
• Organism: Serinicoccus marinus DSM 15273

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FU792_RS14040
• Protein ID: WP_022926035.1
• Coordinates: 2910782..2911192 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FU792_RS14035
• Protein ID: WP_022926033.1
• Coordinates: 2910416..2910643 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU792_RS14005	2905744..2907315	-	1572	WP_022926029.1	Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha	-
FU792_RS14010	2907483..2908331	-	849	WP_028131206.1	ABC transporter ATP-binding protein	-
FU792_RS14015	2908324..2909397	-	1074	WP_033419084.1	ABC transporter ATP-binding protein	-
FU792_RS14020	2909379..2909744	-	366	WP_022926030.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FU792_RS14025	2909737..2909985	-	249	WP_022926031.1	hypothetical protein	-
FU792_RS14030	2910082..2910429	-	348	WP_022926032.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FU792_RS14035	2910416..2910643	-	228	WP_022926033.1	ribbon-helix-helix domain-containing protein	Antitoxin
FU792_RS14040	2910782..2911192	-	411	WP_022926035.1	PIN domain nuclease	Toxin
FU792_RS14045	2911189..2911401	-	213	WP_022926036.1	type II toxin-antitoxin system VapB family antitoxin	-
FU792_RS14050	2911444..2912550	-	1107	WP_149814837.1	FtsX-like permease family protein	-
FU792_RS14055	2912547..2913248	-	702	WP_022926038.1	ATP-binding cassette domain-containing protein	-
FU792_RS14060	2913252..2914082	-	831	WP_161600264.1	peptidoglycan-binding protein	-
FU792_RS16860	2914751..2915311	-	561	WP_022926040.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-37)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14664.78 Da
• Isoelectric Point: 4.6194

>T139242 WP_022926035.1 NZ_CP043808:c2911192-2910782 [Serinicoccus marinus DSM 15273]
VILADTSAWVEYDRATGSPVDERMAELIASGSSLAVTEPVMMEVLARARTADREDDLRRLLLSVTLLPVEPVADFDAAAR
IYRRCRESGVTPRGLLNCLIAAVGWRHGASLLAHDVDLDRVAGVVGLPLDDASLRA

Nucleotide

• Length: 411 bp

>T139242 NZ_CP058596:c45417-45040 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCACCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATGACATTAGCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8045.86 Da
• Isoelectric Point: 4.3569

>AT139242 WP_022926033.1 NZ_CP043808:c2910643-2910416 [Serinicoccus marinus DSM 15273]
MKVSISLSAEDLGALDRYARQAGLASRSAAVQAAIRRLPDAEIENDYAQAWDEWAKGDGGRWESVVGDGLADAPR

Nucleotide

• Length: 228 bp

>AT139242 NZ_CP058596:c45838-45464 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA