Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2910082..2910643 Replicon chromosome
Accession NZ_CP043808
Organism Serinicoccus marinus DSM 15273

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FU792_RS14030 Protein ID WP_022926032.1
Coordinates 2910082..2910429 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FU792_RS14035 Protein ID WP_022926033.1
Coordinates 2910416..2910643 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU792_RS14005 2905744..2907315 - 1572 WP_022926029.1 Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha -
FU792_RS14010 2907483..2908331 - 849 WP_028131206.1 ABC transporter ATP-binding protein -
FU792_RS14015 2908324..2909397 - 1074 WP_033419084.1 ABC transporter ATP-binding protein -
FU792_RS14020 2909379..2909744 - 366 WP_022926030.1 type II toxin-antitoxin system PemK/MazF family toxin -
FU792_RS14025 2909737..2909985 - 249 WP_022926031.1 hypothetical protein -
FU792_RS14030 2910082..2910429 - 348 WP_022926032.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FU792_RS14035 2910416..2910643 - 228 WP_022926033.1 ribbon-helix-helix domain-containing protein Antitoxin
FU792_RS14040 2910782..2911192 - 411 WP_022926035.1 PIN domain nuclease -
FU792_RS14045 2911189..2911401 - 213 WP_022926036.1 type II toxin-antitoxin system VapB family antitoxin -
FU792_RS14050 2911444..2912550 - 1107 WP_149814837.1 FtsX-like permease family protein -
FU792_RS14055 2912547..2913248 - 702 WP_022926038.1 ATP-binding cassette domain-containing protein -
FU792_RS14060 2913252..2914082 - 831 WP_161600264.1 peptidoglycan-binding protein -
FU792_RS16860 2914751..2915311 - 561 WP_022926040.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12507.41 Da        Isoelectric Point: 10.1786

>T139241 WP_022926032.1 NZ_CP043808:c2910429-2910082 [Serinicoccus marinus DSM 15273]
MLRGEIRLVDLDPTRGSEADKRRPAVLVSNDRANTTAARLGRGVVTVVPVTSAVERIYPFQVLLPADETSLRVDSKAQAE
QVRSVDVRRVGAAVGRVPTPLMVDLEDALRVHLAL

Download         Length: 348 bp

>T139241 NZ_CP058594:c3284458-3284108 [Weizmannia coagulans]
TTGATTGTTAAGCGTGGAGACGTGTACTTCGCCGATCTATCTCCGGTGGTCGGCTCCGAGCAGGGAGGCGTACGTCCTGT
CCTCATTTTACAAAACGACATTGGAAACCGTTTTAGCCCCACTGTCATTGTTGCCGCGATAACAGCGCAAATCCAGAAAG
CAAAATTGCCCACGCATGTGGAAATTGATGCAAAGCGTTACGGTTTGGAAAGGGATTCTGTGATATTGCTTGAACAAATA
CGCACAATCGATAAACAACGCTTAACGGATAAGATTACGCATCTTGATGAAGAAGTCATGGAAAAAATTGACGACGCCCT
GCAAATCAGCCTGGGACTGGTCGAATTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8045.86 Da        Isoelectric Point: 4.3569

>AT139241 WP_022926033.1 NZ_CP043808:c2910643-2910416 [Serinicoccus marinus DSM 15273]
MKVSISLSAEDLGALDRYARQAGLASRSAAVQAAIRRLPDAEIENDYAQAWDEWAKGDGGRWESVVGDGLADAPR

Download         Length: 228 bp

>AT139241 NZ_CP058594:c3284741-3284463 [Weizmannia coagulans]
GTGTCTGAACCTATTTCAACAGAAATTTTAGTCCGCTTGCCGCAGCAGCTGTTGACGGAATTGGACGGATTTGCTGAAAC
TGAAAATATGAATCGCAATGAATTAATTTACCGTGCCACAAAAATGTATTTAAAAGAACGGAAAAAACGCCAAATCCGCG
AAACGATGAGGCGTGGTTACATGGAAATGGCAAAAATTAATTTGGCGATTGCCTCCGAAGCGATCCAGGCTGAATACGAA
GCAGAACATACAGTTGAAAGCCTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References