Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2540450..2541122 Replicon chromosome
Accession NZ_CP043808
Organism Serinicoccus marinus DSM 15273

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1NFS6
Locus tag FU792_RS12125 Protein ID WP_022925264.1
Coordinates 2540685..2541122 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FU792_RS12120 Protein ID WP_022925265.1
Coordinates 2540450..2540698 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU792_RS12090 2535862..2536785 - 924 WP_022925269.1 ABC transporter ATP-binding protein -
FU792_RS12095 2536785..2537330 - 546 WP_149814790.1 hypothetical protein -
FU792_RS12100 2537327..2537671 - 345 WP_149814791.1 hypothetical protein -
FU792_RS12105 2537668..2538633 - 966 WP_022925267.1 ABC transporter ATP-binding protein -
FU792_RS12110 2538663..2539240 - 578 Protein_2399 SRPBCC family protein -
FU792_RS12115 2539289..2540335 + 1047 WP_022925266.1 adenosine deaminase -
FU792_RS12120 2540450..2540698 + 249 WP_022925265.1 ribbon-helix-helix protein, CopG family Antitoxin
FU792_RS12125 2540685..2541122 + 438 WP_022925264.1 PIN domain-containing protein Toxin
FU792_RS12130 2541119..2542201 - 1083 WP_149814947.1 UDP-N-acetylmuramate dehydrogenase -
FU792_RS12135 2542267..2542683 - 417 WP_022925262.1 MaoC family dehydratase N-terminal domain-containing protein -
FU792_RS12140 2542680..2543129 - 450 WP_022925261.1 MaoC family dehydratase N-terminal domain-containing protein -
FU792_RS12145 2544214..2544714 + 501 WP_033418902.1 hypothetical protein -
FU792_RS12150 2544756..2545724 + 969 WP_149814793.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-39)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15486.70 Da        Isoelectric Point: 7.1299

>T139239 WP_022925264.1 NZ_CP043808:2540685-2541122 [Serinicoccus marinus DSM 15273]
MLALDVNVLVGALHRGSPGHTTLRPWLERAVDGEEVVGISDAVLTGTLRVVTHPRVFTTPATVPEAAASISNLLRHPNVR
TLRTLAGHWQLVLDLCERAGATGNLVADAAHAATAMQHGATLISDDADFARFPGLAWRRPLDPRP

Download         Length: 438 bp

>T139239 NZ_CP058575:114798-115004 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGGGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9154.21 Da        Isoelectric Point: 5.1239

>AT139239 WP_022925265.1 NZ_CP043808:2540450-2540698 [Serinicoccus marinus DSM 15273]
VRTTIRLPQDLYDEVRETALRERRTVTSLIEESLREALASRSHRRHDAPFSLTPVGGDGGLRPGVDLSDQAALEDLMTDA
RP

Download         Length: 249 bp

>AT139239 NZ_CP058575:c114811-114750 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1NFS6

Antitoxin

Source ID Structure

References