Detailed information of TA system TA139236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 717731..718356
• Replicon: chromosome
• Accession: NZ_CP043808
• Organism: Serinicoccus marinus DSM 15273

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FU792_RS03535
• Protein ID: WP_022924333.1
• Coordinates: 717731..718108 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FU792_RS03540
• Protein ID: WP_022924332.1
• Coordinates: 718105..718356 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU792_RS03500	712842..713942	+	1101	WP_022924340.1	branched-chain amino acid aminotransferase	-
FU792_RS03505	713991..714872	-	882	WP_022924339.1	hypothetical protein	-
FU792_RS03510	715051..715377	+	327	WP_028130895.1	multidrug efflux SMR transporter	-
FU792_RS03515	715409..716188	+	780	WP_022924337.1	fumarylacetoacetate hydrolase family protein	-
FU792_RS03520	716220..716471	+	252	WP_022924336.1	antitoxin	-
FU792_RS03525	716468..716896	+	429	WP_022924335.1	PIN domain-containing protein	-
FU792_RS03530	716910..717737	+	828	WP_022924334.1	glutamate racemase	-
FU792_RS03535	717731..718108	-	378	WP_022924333.1	PIN domain-containing protein	Toxin
FU792_RS03540	718105..718356	-	252	WP_022924332.1	ribbon-helix-helix protein, CopG family	Antitoxin
FU792_RS03545	718487..719743	+	1257	WP_202980400.1	inorganic phosphate transporter	-
FU792_RS17275	719740..720057	+	318	WP_202980401.1	hypothetical protein	-
FU792_RS03550	720198..721610	+	1413	WP_022924330.1	hemolysin family protein	-
FU792_RS03555	721607..722623	+	1017	WP_022924329.1	DUF21 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-37)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13550.65 Da
• Isoelectric Point: 6.9680

>T139236 WP_022924333.1 NZ_CP043808:c718108-717731 [Serinicoccus marinus DSM 15273]
MTALVDTSVLIDTLRGDAAATSLLLSCRRAGPVHASEITRAEVLCGMRSRERRATESLLSTLTWHPLDAGLAELAGDLGR
RWLPSHRGIDTADLVIAATAVHLEVPLLTRNVKHFPMFPDLAAPY

Nucleotide

• Length: 378 bp

>T139236 NZ_CP043808:c718108-717731 [Serinicoccus marinus DSM 15273]
ATGACCGCGCTCGTCGACACCTCCGTGCTCATCGACACGCTGCGCGGTGACGCTGCCGCCACCTCGCTGCTGCTGTCCTG
CCGCCGGGCCGGACCGGTTCATGCCAGCGAGATCACGCGAGCCGAGGTGCTCTGCGGGATGCGCTCTCGCGAGCGGCGGG
CCACCGAGAGCCTTCTCTCCACCCTCACCTGGCACCCCCTCGACGCCGGCCTCGCAGAGCTGGCTGGGGATCTCGGGCGT
CGCTGGCTGCCCAGCCACCGCGGCATCGACACCGCCGATCTCGTCATCGCCGCCACAGCGGTGCACCTCGAGGTCCCGCT
GCTGACGCGCAACGTCAAGCACTTCCCCATGTTCCCCGACCTCGCGGCGCCCTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8821.72 Da
• Isoelectric Point: 5.0152

>AT139236 WP_022924332.1 NZ_CP043808:c718356-718105 [Serinicoccus marinus DSM 15273]
MQRTQISLTAEDRRLLDAAAARTGLSLSRLIRDAVNQTYGAGRDADDDIAAIASASGAWVGRDVDGAGYVETLRSGSRLR
EQA

Nucleotide

• Length: 252 bp

>AT139236 NZ_CP058574:c4573989-4573693 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG