Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 717731..718356 Replicon chromosome
Accession NZ_CP043808
Organism Serinicoccus marinus DSM 15273

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FU792_RS03535 Protein ID WP_022924333.1
Coordinates 717731..718108 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FU792_RS03540 Protein ID WP_022924332.1
Coordinates 718105..718356 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU792_RS03500 712842..713942 + 1101 WP_022924340.1 branched-chain amino acid aminotransferase -
FU792_RS03505 713991..714872 - 882 WP_022924339.1 hypothetical protein -
FU792_RS03510 715051..715377 + 327 WP_028130895.1 multidrug efflux SMR transporter -
FU792_RS03515 715409..716188 + 780 WP_022924337.1 fumarylacetoacetate hydrolase family protein -
FU792_RS03520 716220..716471 + 252 WP_022924336.1 antitoxin -
FU792_RS03525 716468..716896 + 429 WP_022924335.1 PIN domain-containing protein -
FU792_RS03530 716910..717737 + 828 WP_022924334.1 glutamate racemase -
FU792_RS03535 717731..718108 - 378 WP_022924333.1 PIN domain-containing protein Toxin
FU792_RS03540 718105..718356 - 252 WP_022924332.1 ribbon-helix-helix protein, CopG family Antitoxin
FU792_RS03545 718487..719743 + 1257 WP_202980400.1 inorganic phosphate transporter -
FU792_RS17275 719740..720057 + 318 WP_202980401.1 hypothetical protein -
FU792_RS03550 720198..721610 + 1413 WP_022924330.1 hemolysin family protein -
FU792_RS03555 721607..722623 + 1017 WP_022924329.1 DUF21 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13550.65 Da        Isoelectric Point: 6.9680

>T139236 WP_022924333.1 NZ_CP043808:c718108-717731 [Serinicoccus marinus DSM 15273]
MTALVDTSVLIDTLRGDAAATSLLLSCRRAGPVHASEITRAEVLCGMRSRERRATESLLSTLTWHPLDAGLAELAGDLGR
RWLPSHRGIDTADLVIAATAVHLEVPLLTRNVKHFPMFPDLAAPY

Download         Length: 378 bp

>T139236 NZ_CP043808:c718108-717731 [Serinicoccus marinus DSM 15273]
ATGACCGCGCTCGTCGACACCTCCGTGCTCATCGACACGCTGCGCGGTGACGCTGCCGCCACCTCGCTGCTGCTGTCCTG
CCGCCGGGCCGGACCGGTTCATGCCAGCGAGATCACGCGAGCCGAGGTGCTCTGCGGGATGCGCTCTCGCGAGCGGCGGG
CCACCGAGAGCCTTCTCTCCACCCTCACCTGGCACCCCCTCGACGCCGGCCTCGCAGAGCTGGCTGGGGATCTCGGGCGT
CGCTGGCTGCCCAGCCACCGCGGCATCGACACCGCCGATCTCGTCATCGCCGCCACAGCGGTGCACCTCGAGGTCCCGCT
GCTGACGCGCAACGTCAAGCACTTCCCCATGTTCCCCGACCTCGCGGCGCCCTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8821.72 Da        Isoelectric Point: 5.0152

>AT139236 WP_022924332.1 NZ_CP043808:c718356-718105 [Serinicoccus marinus DSM 15273]
MQRTQISLTAEDRRLLDAAAARTGLSLSRLIRDAVNQTYGAGRDADDDIAAIASASGAWVGRDVDGAGYVETLRSGSRLR
EQA

Download         Length: 252 bp

>AT139236 NZ_CP058574:c4573989-4573693 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References