Detailed information of TA system TA139235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 716220..716896
• Replicon: chromosome
• Accession: NZ_CP043808
• Organism: Serinicoccus marinus DSM 15273

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FU792_RS03525
• Protein ID: WP_022924335.1
• Coordinates: 716468..716896 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FU792_RS03520
• Protein ID: WP_022924336.1
• Coordinates: 716220..716471 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU792_RS03495	711685..712551	-	867	WP_022924341.1	ketol-acid reductoisomerase	-
FU792_RS03500	712842..713942	+	1101	WP_022924340.1	branched-chain amino acid aminotransferase	-
FU792_RS03505	713991..714872	-	882	WP_022924339.1	hypothetical protein	-
FU792_RS03510	715051..715377	+	327	WP_028130895.1	multidrug efflux SMR transporter	-
FU792_RS03515	715409..716188	+	780	WP_022924337.1	fumarylacetoacetate hydrolase family protein	-
FU792_RS03520	716220..716471	+	252	WP_022924336.1	antitoxin	Antitoxin
FU792_RS03525	716468..716896	+	429	WP_022924335.1	PIN domain-containing protein	Toxin
FU792_RS03530	716910..717737	+	828	WP_022924334.1	glutamate racemase	-
FU792_RS03535	717731..718108	-	378	WP_022924333.1	PIN domain-containing protein	-
FU792_RS03540	718105..718356	-	252	WP_022924332.1	ribbon-helix-helix protein, CopG family	-
FU792_RS03545	718487..719743	+	1257	WP_202980400.1	inorganic phosphate transporter	-
FU792_RS17275	719740..720057	+	318	WP_202980401.1	hypothetical protein	-
FU792_RS03550	720198..721610	+	1413	WP_022924330.1	hemolysin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15430.58 Da
• Isoelectric Point: 5.1211

>T139235 WP_022924335.1 NZ_CP043808:716468-716896 [Serinicoccus marinus DSM 15273]
MIVPDVNVLLYAHVDAFPEHDRARTWWEETLSAGRPVGLAPVVVFGFIRIATSRRVLTRPFSVQQAQAVVESWLAQPGVQ
MLDSGREHLGRTLEVLTGVGTAAALTMDAQIAAHAFIEGAAVATHDTDFGRFADLDVVDPVR

Nucleotide

• Length: 429 bp

>T139235 NZ_CP058574:4359594-4359851 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9504.78 Da
• Isoelectric Point: 6.8803

>AT139235 WP_022924336.1 NZ_CP043808:716220-716471 [Serinicoccus marinus DSM 15273]
MRTTLTLDADVVRLLEQAVHDRRTSMKSVVNDALRQALRPAQAPRPYRVDVHHSELVVGVDPARLNQLADELEDETIVDK
RHR

Nucleotide

• Length: 252 bp

>AT139235 NZ_CP058574:4359863-4360408 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA