Detailed information of TA system TA139234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 262879..263408
• Replicon: chromosome
• Accession: NZ_CP043808
• Organism: Serinicoccus marinus DSM 15273

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A1B1NCA9
• Locus tag: FU792_RS01300
• Protein ID: WP_022923225.1
• Coordinates: 262879..263205 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FU792_RS01305
• Protein ID: WP_022926329.1
• Coordinates: 263202..263408 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU792_RS01265	258437..258841	+	405	WP_022923227.1	hypothetical protein	-
FU792_RS01270	258834..259037	+	204	WP_022923226.1	helix-turn-helix transcriptional regulator	-
FU792_RS01275	259219..259545	-	327	WP_022923225.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FU792_RS01280	259542..259748	-	207	WP_066638586.1	DUF3018 family protein	-
FU792_RS01285	259934..260986	-	1053	WP_022926335.1	hypothetical protein	-
FU792_RS01290	261041..262338	+	1298	Protein_256	IS3 family transposase	-
FU792_RS01295	262505..262765	-	261	WP_149814479.1	hypothetical protein	-
FU792_RS01300	262879..263205	-	327	WP_022923225.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FU792_RS01305	263202..263408	-	207	WP_022926329.1	DUF3018 family protein	Antitoxin
FU792_RS01310	263796..264473	+	678	WP_149814480.1	hypothetical protein	-
FU792_RS01315	264582..265172	-	591	WP_149814481.1	hypothetical protein	-
FU792_RS01320	265635..265874	+	240	WP_149814482.1	hypothetical protein	-
FU792_RS01325	266552..267316	+	765	WP_052327925.1	transposase family protein	-
FU792_RS01330	267323..267556	+	234	WP_052327924.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	247924..271713	23789

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-106)

Antitoxin

• Antitoxin MazE-like (5-66)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11713.53 Da
• Isoelectric Point: 7.0141

>T139234 WP_022923225.1 NZ_CP043808:c263205-262879 [Serinicoccus marinus DSM 15273]
VRRGELWTVAGGVYASKPRPALIVQDDLFEGTASVTVAPLTTTLVDAPLLRVRVAADDFTGLQHDSQVMIDKVTTVRREN
VGTRIGRLAPESLVEVERALMAFLGLAR

Nucleotide

• Length: 327 bp

>T139234 NZ_CP058574:4307411-4307752 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 8055.02 Da
• Isoelectric Point: 7.0151

>AT139234 WP_022926329.1 NZ_CP043808:c263408-263202 [Serinicoccus marinus DSM 15273]
MTVKHRVSEYRRRMRARGLRPVQIWVPDVRSERFAQEAERQAALVARADKQSDDQEFVEAVTAPWDEE

Nucleotide

• Length: 207 bp

>AT139234 NZ_CP058574:c4307416-4307340 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A1B1NCA9