Detailed information of TA system TA139232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 47132..47657
• Replicon: plasmid p1
• Accession: NZ_CP043774
• Organism: Salmonella enterica strain QH

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: F1527_RS24010
• Protein ID: WP_001159863.1
• Coordinates: 47132..47437 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: F1527_RS24015
• Protein ID: WP_000813641.1
• Coordinates: 47439..47657 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1527_RS23970	42513..43072	-	560	Protein_44	inverse autotransporter beta domain-containing protein	-
F1527_RS23975	43792..44277	-	486	WP_000905606.1	membrane protein	-
F1527_RS23980	44271..44780	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
F1527_RS23990	44784..45497	-	714	Protein_47	EAL domain-containing protein	-
F1527_RS23995	45506..46288	-	783	WP_000082169.1	site-specific integrase	-
F1527_RS24000	46301..46843	-	543	WP_000198609.1	hypothetical protein	-
F1527_RS24005	46840..47130	-	291	WP_001266176.1	hypothetical protein	-
F1527_RS24010	47132..47437	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
F1527_RS24015	47439..47657	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
F1527_RS24020	48333..48854	+	522	WP_011264020.1	hypothetical protein	-
F1527_RS24205	48898..49326	-	429	Protein_54	hypothetical protein	-
F1527_RS24030	49338..49633	+	296	Protein_55	cytoplasmic protein	-
F1527_RS24035	50127..51116	+	990	WP_000461383.1	RepB family plasmid replication initiator protein	-
F1527_RS24040	51234..51395	-	162	WP_001541548.1	hypothetical protein	-
F1527_RS24045	51448..51834	-	387	WP_000751876.1	YgiW/YdeI family stress tolerance OB fold protein	-
F1527_RS24210	52201..52512	-	312	WP_015899541.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55361	55361

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-88)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T139232 WP_001159863.1 NZ_CP043774:c47437-47132 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T139232 NZ_CP058574:c3914423-3914082 [Escherichia coli]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCTGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGATACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCGGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT139232 WP_000813641.1 NZ_CP043774:c47657-47439 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT139232 NZ_CP058574:c3914072-3913773 [Escherichia coli]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGTGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACTCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCGAATGGTAAGAGAATTGCATTTCAGATTTAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6