Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1971447..1972094 Replicon chromosome
Accession NZ_CP043772
Organism Haemophilus influenzae biotype aegyptius strain HE24/F3037

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QVV0
Locus tag F1539_RS10040 Protein ID WP_041174961.1
Coordinates 1971447..1971623 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A5T8
Locus tag F1539_RS10045 Protein ID WP_013526165.1
Coordinates 1971678..1972094 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1539_RS09990 1966950..1967246 + 297 WP_013526169.1 hypothetical protein -
F1539_RS09995 1967255..1967446 + 192 WP_005647090.1 HTH domain-containing protein -
F1539_RS10000 1967447..1968064 + 618 WP_013526168.1 DUF3164 family protein -
F1539_RS10005 1968251..1968448 + 198 WP_006996621.1 ANR family transcriptional regulator -
F1539_RS10250 1968459..1968623 + 165 WP_171034544.1 hypothetical protein -
F1539_RS10010 1968620..1968793 + 174 WP_006996623.1 hypothetical protein -
F1539_RS10015 1968798..1969046 + 249 WP_006996624.1 hypothetical protein -
F1539_RS10020 1969287..1969685 + 399 WP_013526167.1 regulatory protein GemA -
F1539_RS10025 1969712..1969915 + 204 WP_006996626.1 KilA-N domain-containing protein -
F1539_RS10030 1970452..1971093 + 642 WP_013526166.1 antA/AntB antirepressor family protein -
F1539_RS10035 1971104..1971322 + 219 WP_005641522.1 hypothetical protein -
F1539_RS10040 1971447..1971623 + 177 WP_041174961.1 type II toxin-antitoxin system HicA family toxin Toxin
F1539_RS10045 1971678..1972094 + 417 WP_013526165.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1539_RS10050 1972206..1972634 + 429 WP_013526164.1 hypothetical protein -
F1539_RS10055 1972715..1973218 + 504 WP_013526163.1 glycoside hydrolase family 108 protein -
F1539_RS10060 1973372..1973662 + 291 WP_041174960.1 DUF2644 domain-containing protein -
F1539_RS10065 1973662..1973919 + 258 WP_013526161.1 DUF2681 domain-containing protein -
F1539_RS10070 1974043..1974300 + 258 WP_005684166.1 hypothetical protein -
F1539_RS10075 1974300..1974566 + 267 WP_005661915.1 hypothetical protein -
F1539_RS10080 1974568..1975068 + 501 WP_013526160.1 DUF1804 family protein -
F1539_RS10085 1975218..1976867 + 1650 WP_013526159.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-92)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6622.81 Da        Isoelectric Point: 10.6309

>T139230 WP_041174961.1 NZ_CP043772:1971447-1971623 [Haemophilus influenzae biotype aegyptius]
VKQSEFLKWLKANGVEVENGSKHLKLYYQGKISHLPRHPAQELKKGLVEGIKKQLGLK

Download         Length: 177 bp

>T139230 NZ_CP058574:3247285-3247671 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15304.57 Da        Isoelectric Point: 4.2525

>AT139230 WP_013526165.1 NZ_CP043772:1971678-1972094 [Haemophilus influenzae biotype aegyptius]
MFYPATFTPAEEGGYVVTFADLPEAITQGDTIEEAQEMAEDVLISCVEIYFDEERPFPLARACDSDETAVFMPDSVYAKV
LLHNAMLAENVSKAQLARLTYIRPPEIQRILAPRHTTKIDTIAKALLGLGKQLQLSVV

Download         Length: 417 bp

>AT139230 NZ_CP058574:3247661-3247990 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QVV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QY11

References