Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 895800..896450 Replicon chromosome
Accession NZ_CP043772
Organism Haemophilus influenzae biotype aegyptius strain HE24/F3037

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QXL9
Locus tag F1539_RS04555 Protein ID WP_041174880.1
Coordinates 896271..896450 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A7Z3
Locus tag F1539_RS04550 Protein ID WP_013525461.1
Coordinates 895800..896207 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1539_RS04530 891508..892395 - 888 WP_013525457.1 GPO family capsid scaffolding protein -
F1539_RS04535 892599..894403 + 1805 Protein_870 terminase ATPase subunit family protein -
F1539_RS04540 894393..895427 + 1035 WP_013525459.1 phage portal protein -
F1539_RS04545 895509..895769 + 261 WP_013525460.1 ogr/Delta-like zinc finger family protein -
F1539_RS04550 895800..896207 - 408 WP_013525461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1539_RS04555 896271..896450 - 180 WP_041174880.1 type II toxin-antitoxin system HicA family toxin Toxin
F1539_RS04560 896530..897048 - 519 WP_013525462.1 phage N-6-adenine-methyltransferase -
F1539_RS04565 897058..897363 - 306 WP_013525463.1 hypothetical protein -
F1539_RS04570 897375..899714 - 2340 WP_013525464.1 replication endonuclease -
F1539_RS04575 899775..900110 - 336 WP_013525465.1 hypothetical protein -
F1539_RS04580 900129..900632 - 504 WP_013525466.1 hypothetical protein -
F1539_RS04585 900765..901004 - 240 WP_041174881.1 hypothetical protein -
F1539_RS04590 901001..901192 - 192 WP_041174882.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 872721..949812 77091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6686.87 Da        Isoelectric Point: 10.8241

>T139228 WP_041174880.1 NZ_CP043772:c896450-896271 [Haemophilus influenzae biotype aegyptius]
MNSAKIIKQIEDDGWYLVNVVGSHHQFKHPTKKGRVTVPHPKKDLQIKTVKSILKQAGI

Download         Length: 180 bp

>T139228 NZ_CP043772:c896450-896271 [Haemophilus influenzae biotype aegyptius]
ATGAATAGTGCAAAAATAATTAAACAAATTGAGGATGACGGTTGGTATCTTGTAAATGTTGTCGGTAGTCACCATCAATT
CAAGCATCCAACAAAGAAAGGGCGAGTTACTGTTCCACATCCGAAAAAGGATTTACAAATAAAGACGGTAAAATCAATAT
TAAAGCAAGCGGGGATTTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14978.99 Da        Isoelectric Point: 4.3488

>AT139228 WP_013525461.1 NZ_CP043772:c896207-895800 [Haemophilus influenzae biotype aegyptius]
MLYPIGIEMGDENHTYGVVVPDVPGCFSAGDTLEEAFINAKEAITFHIEGLLEDGEEIPQPTSLQEHVKNPEYEGFTFSF
VDVDLTHLMGKAEKINVTLPSLLIKRIDSFVATHPEYKNRSNFLAQVVTNKLLAA

Download         Length: 408 bp

>AT139228 NZ_CP058574:c2828463-2828402 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QXL9

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYR1

References