Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 657876..658411 Replicon chromosome
Accession NZ_CP043772
Organism Haemophilus influenzae biotype aegyptius strain HE24/F3037

Toxin (Protein)


Gene name relE Uniprot ID E7A433
Locus tag F1539_RS03340 Protein ID WP_013525737.1
Coordinates 657876..658139 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A432
Locus tag F1539_RS03345 Protein ID WP_013525736.1
Coordinates 658136..658411 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1539_RS10170 653564..653737 - 174 WP_005652999.1 DUF5363 domain-containing protein -
F1539_RS03325 653734..655704 - 1971 WP_013525739.1 tRNA(Met) cytidine acetyltransferase TmcA -
F1539_RS03330 655709..656050 - 342 WP_006995879.1 SirB2 family protein -
F1539_RS03335 656111..657781 - 1671 WP_013525738.1 energy-dependent translational throttle protein EttA -
F1539_RS03340 657876..658139 - 264 WP_013525737.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
F1539_RS03345 658136..658411 - 276 WP_013525736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F1539_RS03350 658761..659381 + 621 WP_005694310.1 zinc transporter binding subunit ZevA -
F1539_RS03355 659384..660358 + 975 WP_006995878.1 zinc transporter permease subunit ZevB -
F1539_RS03360 660444..661096 - 653 Protein_650 IS1595 family transposase -
F1539_RS03365 661159..661218 + 60 WP_086935109.1 hypothetical protein -
F1539_RS03370 661262..662398 - 1137 WP_013525733.1 DUF2827 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 660521..661096 575


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10201.90 Da        Isoelectric Point: 7.8978

>T139227 WP_013525737.1 NZ_CP043772:c658139-657876 [Haemophilus influenzae biotype aegyptius]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

>T139227 NZ_CP043772:c658139-657876 [Haemophilus influenzae biotype aegyptius]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10259.81 Da        Isoelectric Point: 6.0646

>AT139227 WP_013525736.1 NZ_CP043772:c658411-658136 [Haemophilus influenzae biotype aegyptius]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT139227 NZ_CP058574:c2600964-2600548 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QSH1

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R2R7

References