Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 459786..460439 Replicon chromosome
Accession NZ_CP043772
Organism Haemophilus influenzae biotype aegyptius strain HE24/F3037

Toxin (Protein)


Gene name vapC Uniprot ID E7A495
Locus tag F1539_RS02345 Protein ID WP_013525780.1
Coordinates 460047..460439 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C2R5S0
Locus tag F1539_RS02340 Protein ID WP_006996057.1
Coordinates 459786..460046 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1539_RS02325 455636..456601 - 966 WP_013525778.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
F1539_RS02330 456598..458112 - 1515 WP_041174913.1 sodium/proline symporter PutP -
F1539_RS02335 458228..459703 + 1476 WP_006996058.1 ribonuclease G -
F1539_RS02340 459786..460046 + 261 WP_006996057.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F1539_RS02345 460047..460439 + 393 WP_013525780.1 type II toxin-antitoxin system VapC family toxin Toxin
F1539_RS02350 460789..462177 + 1389 WP_149998745.1 YadA-like family protein -
F1539_RS02355 462374..464041 + 1668 WP_013525782.1 glutamine--tRNA ligase -
F1539_RS02360 464119..464550 + 432 WP_013525783.1 YcgN family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14724.18 Da        Isoelectric Point: 4.6908

>T139225 WP_013525780.1 NZ_CP043772:460047-460439 [Haemophilus influenzae biotype aegyptius]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFELVPNLILENWCSV

Download         Length: 393 bp

>T139225 NZ_CP058574:2499525-2500847 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACCGTCGCTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10301.56 Da        Isoelectric Point: 4.9010

>AT139225 WP_006996057.1 NZ_CP043772:459786-460046 [Haemophilus influenzae biotype aegyptius]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Download         Length: 261 bp

>AT139225 NZ_CP043772:459786-460046 [Haemophilus influenzae biotype aegyptius]
ATGGAAAAAATCGCACGTTTATTTAGAAATGGTCGCAATCAAGCCGTTCGTTTACCTGTGGAATTTGAGTTTGACGCCAC
TCAAATTTATGTTTTCAAAGAAGAAAATGGCGATATTAGGCTTTCAACTCGTTCTCGTAGCCAGCAAAATTGGCAGAAAG
TCTTCGAATTGTTACCTACAATTCAATGTGATGAAGATTTTTTATCAGAAAAAGAGCGTAAGCAAGAAGTGGCAACGCGA
GATCCTTTTGAGGGCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2R1L6

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R5S0

References