Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1949719..1950369 Replicon chromosome
Accession NZ_CP043771
Organism Haemophilus influenzae biotype aegyptius strain HE15/F3028

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QXL9
Locus tag F1538_RS09885 Protein ID WP_041174880.1
Coordinates 1949719..1949898 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A7Z3
Locus tag F1538_RS09890 Protein ID WP_013525461.1
Coordinates 1949962..1950369 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1538_RS09850 1944977..1945168 + 192 WP_041174882.1 hypothetical protein -
F1538_RS09855 1945165..1945404 + 240 WP_041174881.1 hypothetical protein -
F1538_RS09860 1945537..1946040 + 504 WP_013525466.1 hypothetical protein -
F1538_RS09865 1946059..1946394 + 336 WP_013525465.1 hypothetical protein -
F1538_RS09870 1946455..1948794 + 2340 WP_013525464.1 replication endonuclease -
F1538_RS09875 1948806..1949111 + 306 WP_013525463.1 hypothetical protein -
F1538_RS09880 1949121..1949639 + 519 WP_013525462.1 phage N-6-adenine-methyltransferase -
F1538_RS09885 1949719..1949898 + 180 WP_041174880.1 type II toxin-antitoxin system HicA family toxin Toxin
F1538_RS09890 1949962..1950369 + 408 WP_013525461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1538_RS09895 1950400..1950660 - 261 WP_013525460.1 ogr/Delta-like zinc finger family protein -
F1538_RS09900 1950742..1951776 - 1035 WP_013525459.1 phage portal protein -
F1538_RS09905 1951766..1953570 - 1805 Protein_1893 terminase ATPase subunit family protein -
F1538_RS09910 1953774..1954661 + 888 WP_013525457.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1896357..1973448 77091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6686.87 Da        Isoelectric Point: 10.8241

>T139224 WP_041174880.1 NZ_CP043771:1949719-1949898 [Haemophilus influenzae biotype aegyptius]
MNSAKIIKQIEDDGWYLVNVVGSHHQFKHPTKKGRVTVPHPKKDLQIKTVKSILKQAGI

Download         Length: 180 bp

>T139224 NZ_CP043771:1949719-1949898 [Haemophilus influenzae biotype aegyptius]
ATGAATAGTGCAAAAATAATTAAACAAATTGAGGATGACGGTTGGTATCTTGTAAATGTTGTCGGTAGTCACCATCAATT
CAAGCATCCAACAAAGAAAGGGCGAGTTACTGTTCCACATCCGAAAAAGGATTTACAAATAAAGACGGTAAAATCAATAT
TAAAGCAAGCGGGGATTTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14978.99 Da        Isoelectric Point: 4.3488

>AT139224 WP_013525461.1 NZ_CP043771:1949962-1950369 [Haemophilus influenzae biotype aegyptius]
MLYPIGIEMGDENHTYGVVVPDVPGCFSAGDTLEEAFINAKEAITFHIEGLLEDGEEIPQPTSLQEHVKNPEYEGFTFSF
VDVDLTHLMGKAEKINVTLPSLLIKRIDSFVATHPEYKNRSNFLAQVVTNKLLAA

Download         Length: 408 bp

>AT139224 NZ_CP058574:c2147178-2146907 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QXL9

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYR1

References