Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1015085..1015732 Replicon chromosome
Accession NZ_CP043771
Organism Haemophilus influenzae biotype aegyptius strain HE15/F3028

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QVV0
Locus tag F1538_RS05015 Protein ID WP_041174961.1
Coordinates 1015556..1015732 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A5T8
Locus tag F1538_RS05010 Protein ID WP_013526165.1
Coordinates 1015085..1015501 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1538_RS04970 1010312..1011961 - 1650 WP_013526159.1 phage terminase large subunit -
F1538_RS04975 1012111..1012611 - 501 WP_013526160.1 DUF1804 family protein -
F1538_RS04980 1012613..1012879 - 267 WP_005661915.1 hypothetical protein -
F1538_RS04985 1012879..1013136 - 258 WP_005684166.1 hypothetical protein -
F1538_RS04990 1013260..1013517 - 258 WP_013526161.1 DUF2681 domain-containing protein -
F1538_RS04995 1013517..1013807 - 291 WP_041174960.1 DUF2644 domain-containing protein -
F1538_RS10170 1013804..1013971 - 168 WP_171034543.1 hypothetical protein -
F1538_RS05000 1013961..1014464 - 504 WP_013526163.1 glycoside hydrolase family 108 protein -
F1538_RS05005 1014545..1014973 - 429 WP_013526164.1 hypothetical protein -
F1538_RS05010 1015085..1015501 - 417 WP_013526165.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1538_RS05015 1015556..1015732 - 177 WP_041174961.1 type II toxin-antitoxin system HicA family toxin Toxin
F1538_RS05020 1015857..1016075 - 219 WP_005641522.1 hypothetical protein -
F1538_RS05025 1016086..1016727 - 642 WP_013526166.1 antA/AntB antirepressor family protein -
F1538_RS05030 1017264..1017467 - 204 WP_006996626.1 KilA-N domain-containing protein -
F1538_RS05035 1017494..1017892 - 399 WP_013526167.1 regulatory protein GemA -
F1538_RS05040 1018133..1018381 - 249 WP_006996624.1 hypothetical protein -
F1538_RS05045 1018386..1018559 - 174 WP_006996623.1 hypothetical protein -
F1538_RS10175 1018556..1018720 - 165 WP_171034544.1 hypothetical protein -
F1538_RS05050 1018731..1018928 - 198 WP_006996621.1 ANR family transcriptional regulator -
F1538_RS05055 1019115..1019732 - 618 WP_013526168.1 DUF3164 family protein -
F1538_RS05060 1019733..1019924 - 192 WP_005647090.1 HTH domain-containing protein -
F1538_RS05065 1019933..1020229 - 297 WP_013526169.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1004206..1037633 33427


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-92)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6622.81 Da        Isoelectric Point: 10.6309

>T139222 WP_041174961.1 NZ_CP043771:c1015732-1015556 [Haemophilus influenzae biotype aegyptius]
VKQSEFLKWLKANGVEVENGSKHLKLYYQGKISHLPRHPAQELKKGLVEGIKKQLGLK

Download         Length: 177 bp

>T139222 NZ_CP058574:908379-908786 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGAAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGTGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15304.57 Da        Isoelectric Point: 4.2525

>AT139222 WP_013526165.1 NZ_CP043771:c1015501-1015085 [Haemophilus influenzae biotype aegyptius]
MFYPATFTPAEEGGYVVTFADLPEAITQGDTIEEAQEMAEDVLISCVEIYFDEERPFPLARACDSDETAVFMPDSVYAKV
LLHNAMLAENVSKAQLARLTYIRPPEIQRILAPRHTTKIDTIAKALLGLGKQLQLSVV

Download         Length: 417 bp

>AT139222 NZ_CP043771:c1015501-1015085 [Haemophilus influenzae biotype aegyptius]
ATGTTTTACCCAGCAACCTTTACCCCCGCCGAAGAAGGCGGTTATGTCGTCACCTTTGCAGATTTGCCAGAAGCGATTAC
ACAAGGCGATACCATAGAAGAAGCGCAAGAAATGGCGGAAGATGTGTTGATTTCTTGTGTAGAAATCTACTTTGATGAAG
AACGCCCTTTCCCATTGGCTCGTGCATGCGATAGTGATGAAACTGCGGTATTTATGCCCGATAGCGTGTATGCTAAAGTG
CTGTTGCATAATGCGATGTTGGCAGAAAATGTATCAAAAGCACAATTAGCGCGCTTAACCTATATTCGTCCGCCTGAAAT
TCAGCGTATTCTTGCGCCACGCCATACGACAAAAATTGATACGATTGCCAAAGCATTGTTAGGCTTAGGCAAGCAATTAC
AACTTTCTGTCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QVV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QY11

References