Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 418191..418844 Replicon chromosome
Accession NZ_CP043771
Organism Haemophilus influenzae biotype aegyptius strain HE15/F3028

Toxin (Protein)


Gene name vapC Uniprot ID E7A495
Locus tag F1538_RS01960 Protein ID WP_013525780.1
Coordinates 418452..418844 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C2R5S0
Locus tag F1538_RS01955 Protein ID WP_006996057.1
Coordinates 418191..418451 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1538_RS01940 414041..415006 - 966 WP_013525778.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
F1538_RS01945 415003..416517 - 1515 WP_041174913.1 sodium/proline symporter PutP -
F1538_RS01950 416633..418108 + 1476 WP_006996058.1 ribonuclease G -
F1538_RS01955 418191..418451 + 261 WP_006996057.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F1538_RS01960 418452..418844 + 393 WP_013525780.1 type II toxin-antitoxin system VapC family toxin Toxin
F1538_RS01965 419277..420578 + 1302 WP_149998798.1 YadA-like family protein -
F1538_RS01970 420775..422442 + 1668 WP_013525782.1 glutamine--tRNA ligase -
F1538_RS01975 422520..422951 + 432 WP_013525783.1 YcgN family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14724.18 Da        Isoelectric Point: 4.6908

>T139221 WP_013525780.1 NZ_CP043771:418452-418844 [Haemophilus influenzae biotype aegyptius]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFELVPNLILENWCSV

Download         Length: 393 bp

>T139221 NZ_CP058574:c800645-800268 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10301.56 Da        Isoelectric Point: 4.9010

>AT139221 WP_006996057.1 NZ_CP043771:418191-418451 [Haemophilus influenzae biotype aegyptius]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Download         Length: 261 bp

>AT139221 NZ_CP058574:c801069-800692 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2R1L6

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R5S0

References