Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 340790..341325 Replicon chromosome
Accession NZ_CP043771
Organism Haemophilus influenzae biotype aegyptius strain HE15/F3028

Toxin (Protein)


Gene name relE Uniprot ID E7A433
Locus tag F1538_RS01585 Protein ID WP_013525737.1
Coordinates 341062..341325 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A432
Locus tag F1538_RS01580 Protein ID WP_013525736.1
Coordinates 340790..341065 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1538_RS01555 336803..337939 + 1137 WP_013525733.1 DUF2827 family protein -
F1538_RS01560 337983..338078 - 96 Protein_295 IS3 family transposase -
F1538_RS01565 338105..338757 + 653 Protein_296 IS1595 family transposase -
F1538_RS01570 338843..339817 - 975 WP_006995878.1 zinc transporter permease subunit ZevB -
F1538_RS01575 339820..340440 - 621 WP_005694310.1 zinc transporter binding subunit ZevA -
F1538_RS01580 340790..341065 + 276 WP_013525736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F1538_RS01585 341062..341325 + 264 WP_013525737.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
F1538_RS01590 341420..343090 + 1671 WP_013525738.1 energy-dependent translational throttle protein EttA -
F1538_RS01595 343151..343492 + 342 WP_006995879.1 SirB2 family protein -
F1538_RS01600 343497..345467 + 1971 WP_013525739.1 tRNA(Met) cytidine acetyltransferase TmcA -
F1538_RS10120 345464..345637 + 174 WP_005652999.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 338105..338680 575


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10201.90 Da        Isoelectric Point: 7.8978

>T139219 WP_013525737.1 NZ_CP043771:341062-341325 [Haemophilus influenzae biotype aegyptius]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

>T139219 NZ_CP043771:341062-341325 [Haemophilus influenzae biotype aegyptius]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10259.81 Da        Isoelectric Point: 6.0646

>AT139219 WP_013525736.1 NZ_CP043771:340790-341065 [Haemophilus influenzae biotype aegyptius]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT139219 NZ_CP058574:678060-678476 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACGCCCAGGCGCTGGAACTGGTCGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QSH1

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R2R7

References