Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1833192..1833839 Replicon chromosome
Accession NZ_CP043770
Organism Haemophilus influenzae biotype aegyptius strain HE7/F1946

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QVV0
Locus tag F1537_RS09415 Protein ID WP_041174961.1
Coordinates 1833192..1833368 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A5T8
Locus tag F1537_RS09420 Protein ID WP_013526165.1
Coordinates 1833423..1833839 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1537_RS09365 1828694..1828990 + 297 WP_013526169.1 hypothetical protein -
F1537_RS09370 1828999..1829190 + 192 WP_005647090.1 HTH domain-containing protein -
F1537_RS09375 1829191..1829808 + 618 WP_013526168.1 DUF3164 family protein -
F1537_RS09380 1829995..1830192 + 198 WP_006996621.1 ANR family transcriptional regulator -
F1537_RS10250 1830203..1830367 + 165 WP_171034544.1 hypothetical protein -
F1537_RS09385 1830364..1830537 + 174 WP_006996623.1 hypothetical protein -
F1537_RS09390 1830542..1830790 + 249 WP_006996624.1 hypothetical protein -
F1537_RS09395 1831031..1831429 + 399 WP_013526167.1 regulatory protein GemA -
F1537_RS09400 1831456..1831659 + 204 WP_006996626.1 KilA-N domain-containing protein -
F1537_RS09405 1832196..1832837 + 642 WP_013526166.1 antA/AntB antirepressor family protein -
F1537_RS09410 1832848..1833066 + 219 WP_005641522.1 hypothetical protein -
F1537_RS09415 1833192..1833368 + 177 WP_041174961.1 type II toxin-antitoxin system HicA family toxin Toxin
F1537_RS09420 1833423..1833839 + 417 WP_013526165.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1537_RS09425 1833951..1834379 + 429 WP_013526164.1 hypothetical protein -
F1537_RS09430 1834460..1834963 + 504 WP_013526163.1 glycoside hydrolase family 108 protein -
F1537_RS09435 1835117..1835407 + 291 WP_041174960.1 DUF2644 domain-containing protein -
F1537_RS09440 1835407..1835664 + 258 WP_013526161.1 DUF2681 domain-containing protein -
F1537_RS09445 1835788..1836045 + 258 WP_005684166.1 hypothetical protein -
F1537_RS09450 1836045..1836311 + 267 WP_005661915.1 hypothetical protein -
F1537_RS09455 1836313..1836813 + 501 WP_013526160.1 DUF1804 family protein -
F1537_RS09460 1836963..1838612 + 1650 WP_013526159.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1816281..1844718 28437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-92)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6622.81 Da        Isoelectric Point: 10.6309

>T139218 WP_041174961.1 NZ_CP043770:1833192-1833368 [Haemophilus influenzae biotype aegyptius]
VKQSEFLKWLKANGVEVENGSKHLKLYYQGKISHLPRHPAQELKKGLVEGIKKQLGLK

Download         Length: 177 bp

>T139218 NZ_CP043770:1833192-1833368 [Haemophilus influenzae biotype aegyptius]
GTGAAACAAAGTGAGTTCCTAAAATGGCTAAAAGCCAATGGGGTTGAAGTTGAAAATGGTTCAAAACATTTGAAACTTTA
CTACCAAGGCAAAATAAGCCACTTACCCCGCCACCCAGCGCAAGAATTGAAAAAGGGTTTGGTGGAAGGGATTAAGAAAC
AGTTAGGATTAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15304.57 Da        Isoelectric Point: 4.2525

>AT139218 WP_013526165.1 NZ_CP043770:1833423-1833839 [Haemophilus influenzae biotype aegyptius]
MFYPATFTPAEEGGYVVTFADLPEAITQGDTIEEAQEMAEDVLISCVEIYFDEERPFPLARACDSDETAVFMPDSVYAKV
LLHNAMLAENVSKAQLARLTYIRPPEIQRILAPRHTTKIDTIAKALLGLGKQLQLSVV

Download         Length: 417 bp

>AT139218 NZ_CP058574:c635499-635164 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACACC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QVV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QY11

References