Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 997811..998461 Replicon chromosome
Accession NZ_CP043770
Organism Haemophilus influenzae biotype aegyptius strain HE7/F1946

Toxin (Protein)


Gene name hicA Uniprot ID A0A5C2QXL9
Locus tag F1537_RS05200 Protein ID WP_041174880.1
Coordinates 997811..997990 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E7A7Z3
Locus tag F1537_RS05205 Protein ID WP_013525461.1
Coordinates 998054..998461 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1537_RS05165 993069..993260 + 192 WP_041174882.1 hypothetical protein -
F1537_RS05170 993257..993496 + 240 WP_041174881.1 hypothetical protein -
F1537_RS05175 993629..994132 + 504 WP_013525466.1 hypothetical protein -
F1537_RS05180 994151..994486 + 336 WP_013525465.1 hypothetical protein -
F1537_RS05185 994547..996886 + 2340 WP_013525464.1 replication endonuclease -
F1537_RS05190 996898..997203 + 306 WP_013525463.1 hypothetical protein -
F1537_RS05195 997213..997731 + 519 WP_013525462.1 phage N-6-adenine-methyltransferase -
F1537_RS05200 997811..997990 + 180 WP_041174880.1 type II toxin-antitoxin system HicA family toxin Toxin
F1537_RS05205 998054..998461 + 408 WP_013525461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1537_RS05210 998492..998752 - 261 WP_013525460.1 ogr/Delta-like zinc finger family protein -
F1537_RS05215 998834..999868 - 1035 WP_013525459.1 phage portal protein -
F1537_RS05220 999858..1001662 - 1805 Protein_998 terminase ATPase subunit family protein -
F1537_RS05225 1001866..1002753 + 888 WP_013525457.1 GPO family capsid scaffolding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 990209..1021542 31333


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6686.87 Da        Isoelectric Point: 10.8241

>T139216 WP_041174880.1 NZ_CP043770:997811-997990 [Haemophilus influenzae biotype aegyptius]
MNSAKIIKQIEDDGWYLVNVVGSHHQFKHPTKKGRVTVPHPKKDLQIKTVKSILKQAGI

Download         Length: 180 bp

>T139216 NZ_CP058572:c57548-57267 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14978.99 Da        Isoelectric Point: 4.3488

>AT139216 WP_013525461.1 NZ_CP043770:998054-998461 [Haemophilus influenzae biotype aegyptius]
MLYPIGIEMGDENHTYGVVVPDVPGCFSAGDTLEEAFINAKEAITFHIEGLLEDGEEIPQPTSLQEHVKNPEYEGFTFSF
VDVDLTHLMGKAEKINVTLPSLLIKRIDSFVATHPEYKNRSNFLAQVVTNKLLAA

Download         Length: 408 bp

>AT139216 NZ_CP058572:c57814-57545 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QXL9

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYR1

References