Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 444249..444902 Replicon chromosome
Accession NZ_CP043770
Organism Haemophilus influenzae biotype aegyptius strain HE7/F1946

Toxin (Protein)


Gene name vapC Uniprot ID E7A495
Locus tag F1537_RS02345 Protein ID WP_013525780.1
Coordinates 444249..444641 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C2R5S0
Locus tag F1537_RS02350 Protein ID WP_006996057.1
Coordinates 444642..444902 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1537_RS02330 440122..440553 - 432 WP_013525783.1 YcgN family cysteine cluster protein -
F1537_RS02335 440631..442298 - 1668 WP_013525782.1 glutamine--tRNA ligase -
F1537_RS02340 442495..443899 - 1405 Protein_452 YadA-like family protein -
F1537_RS02345 444249..444641 - 393 WP_013525780.1 type II toxin-antitoxin system VapC family toxin Toxin
F1537_RS02350 444642..444902 - 261 WP_006996057.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F1537_RS02355 444985..446460 - 1476 WP_006996058.1 ribonuclease G -
F1537_RS02360 446576..448090 + 1515 WP_041174913.1 sodium/proline symporter PutP -
F1537_RS02365 448087..449052 + 966 WP_013525778.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14724.18 Da        Isoelectric Point: 4.6908

>T139213 WP_013525780.1 NZ_CP043770:c444641-444249 [Haemophilus influenzae biotype aegyptius]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFELVPNLILENWCSV

Download         Length: 393 bp

>T139213 NZ_CP058571:4100541-4100819 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10301.56 Da        Isoelectric Point: 4.9010

>AT139213 WP_006996057.1 NZ_CP043770:c444902-444642 [Haemophilus influenzae biotype aegyptius]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Download         Length: 261 bp

>AT139213 NZ_CP058571:4100278-4100538 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2R1L6

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R5S0

References