Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 97794..98320 Replicon plasmid pIMPIncH12_331kb
Accession NZ_CP043767
Organism Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag F1597_RS24690 Protein ID WP_000323025.1
Coordinates 98033..98320 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag F1597_RS24685 Protein ID WP_000534858.1
Coordinates 97794..98033 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1597_RS24665 94122..95360 + 1239 WP_000219087.1 IS110 family transposase -
F1597_RS24670 95836..96408 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
F1597_RS24675 96608..97531 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
F1597_RS24685 97794..98033 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
F1597_RS24690 98033..98320 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
F1597_RS24695 98392..98550 + 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
F1597_RS24700 99159..99479 - 321 WP_000332796.1 hypothetical protein -
F1597_RS24705 99761..99964 - 204 WP_001015183.1 hypothetical protein -
F1597_RS24710 100011..100361 - 351 WP_000743059.1 hypothetical protein -
F1597_RS24715 100421..101023 - 603 WP_012695474.1 hypothetical protein -
F1597_RS24720 101119..102063 - 945 WP_000778029.1 DUF5417 domain-containing protein -
F1597_RS26820 102574..102750 + 177 WP_001371930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrA1 / sul1 / blaIMP-70 / qacE / dfrA19 / aph(3'')-Ib / aph(6)-Id / mcr-9 / catA2 / blaTEM-1B - 1..331049 331049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T139211 WP_000323025.1 NZ_CP043767:98033-98320 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T139211 NZ_CP058571:3891630-3891848 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT139211 WP_000534858.1 NZ_CP043767:97794-98033 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT139211 NZ_CP058571:3891230-3891604 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References