139211

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 97794..98320 Replicon plasmid pIMPIncH12_331kb
Accession NZ_CP043767
Organism Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag F1597_RS24690 Protein ID WP_000323025.1
Coordinates 98033..98320 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag F1597_RS24685 Protein ID WP_000534858.1
Coordinates 97794..98033 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1597_RS24665 94122..95360 + 1239 WP_000219087.1 IS110 family transposase -
F1597_RS24670 95836..96408 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
F1597_RS24675 96608..97531 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
F1597_RS24685 97794..98033 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
F1597_RS24690 98033..98320 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
F1597_RS24695 98392..98550 + 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
F1597_RS24700 99159..99479 - 321 WP_000332796.1 hypothetical protein -
F1597_RS24705 99761..99964 - 204 WP_001015183.1 hypothetical protein -
F1597_RS24710 100011..100361 - 351 WP_000743059.1 hypothetical protein -
F1597_RS24715 100421..101023 - 603 WP_012695474.1 hypothetical protein -
F1597_RS24720 101119..102063 - 945 WP_000778029.1 DUF5417 domain-containing protein -
F1597_RS26820 102574..102750 + 177 WP_001371930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrA1 / sul1 / blaIMP-70 / qacE / dfrA19 / aph(3'')-Ib / aph(6)-Id / mcr-9 / catA2 / blaTEM-1B - 1..331049 331049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T139211 WP_000323025.1 NZ_CP043767:98033-98320 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T139211 NZ_CP058571:3891630-3891848 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT139211 WP_000534858.1 NZ_CP043767:97794-98033 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT139211 NZ_CP058571:3891230-3891604 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References