Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4407763..4408502 Replicon chromosome
Accession NZ_CP043766
Organism Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag F1597_RS21505 Protein ID WP_003857133.1
Coordinates 4407763..4408248 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag F1597_RS21510 Protein ID WP_003857131.1
Coordinates 4408236..4408502 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1597_RS21475 4403341..4403886 + 546 WP_033487950.1 NUDIX hydrolase -
F1597_RS21480 4404070..4404706 - 637 Protein_4130 DUF421 domain-containing protein -
F1597_RS21485 4404716..4405162 - 447 WP_032671143.1 DUF3290 domain-containing protein -
F1597_RS21490 4405440..4405907 - 468 Protein_4132 hypothetical protein -
F1597_RS21495 4406162..4407127 + 966 WP_033487773.1 hypothetical protein -
F1597_RS21500 4407143..4407712 + 570 WP_033487774.1 hypothetical protein -
F1597_RS21505 4407763..4408248 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
F1597_RS21510 4408236..4408502 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
F1597_RS21515 4408566..4409495 - 930 WP_017693416.1 LysR family transcriptional regulator -
F1597_RS21520 4409625..4411007 + 1383 WP_033487775.1 MFS transporter -
F1597_RS21525 4411029..4412024 - 996 WP_033487776.1 DUF2891 domain-containing protein -
F1597_RS21530 4412034..4413020 - 987 WP_059443774.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T139202 WP_003857133.1 NZ_CP043766:c4408248-4407763 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T139202 NZ_CP058571:1926002-1926253 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGATTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT139202 WP_003857131.1 NZ_CP043766:c4408502-4408236 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT139202 NZ_CP058571:1926250-1926504 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References