Detailed information of TA system TA139198

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 2959012..2959727
• Replicon: chromosome
• Accession: NZ_CP043766
• Organism: Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A8I0UM05
• Locus tag: F1597_RS14140
• Protein ID: WP_023303149.1
• Coordinates: 2959359..2959727 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8I0UJV2
• Locus tag: F1597_RS14135
• Protein ID: WP_023303148.1
• Coordinates: 2959012..2959338 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1597_RS14105	2954046..2955311	+	1266	WP_023303143.1	hypothetical protein	-
F1597_RS14110	2955620..2956054	+	435	WP_023303144.1	hypothetical protein	-
F1597_RS14115	2956113..2956952	+	840	WP_023303145.1	hypothetical protein	-
F1597_RS14125	2957642..2958463	+	822	WP_023303146.1	DUF945 domain-containing protein	-
F1597_RS14130	2958529..2958999	+	471	WP_023303147.1	DNA repair protein RadC	-
F1597_RS14135	2959012..2959338	+	327	WP_023303148.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
F1597_RS14140	2959359..2959727	+	369	WP_023303149.1	TA system toxin CbtA family protein	Toxin
F1597_RS14145	2960080..2960826	-	747	WP_033487728.1	class I SAM-dependent methyltransferase	-
F1597_RS14150	2960837..2961094	-	258	WP_003863178.1	YjhX family toxin	-
F1597_RS14155	2961354..2963291	-	1938	WP_032671391.1	bifunctional diguanylate cyclase/phosphodiesterase	-
F1597_RS14160	2963309..2963788	-	480	WP_151574398.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2938095..2959727	21632
	-	flank	IS/Tn	-	-	2963860..2964840	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13727.91 Da
• Isoelectric Point: 8.2822

>T139198 WP_023303149.1 NZ_CP043766:2959359-2959727 [Enterobacter hormaechei]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Nucleotide

• Length: 369 bp

>T139198 NZ_CP058571:c659951-659637 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATTGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12215.04 Da
• Isoelectric Point: 7.0266

>AT139198 WP_023303148.1 NZ_CP043766:2959012-2959338 [Enterobacter hormaechei]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 327 bp

>AT139198 NZ_CP058571:c659640-659224 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA