Detailed information of TA system TA139196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 1872327..1872943
• Replicon: chromosome
• Accession: NZ_CP043766
• Organism: Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F1597_RS08940
• Protein ID: WP_077266491.1
• Coordinates: 1872327..1872698 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6G4MTK3
• Locus tag: F1597_RS08945
• Protein ID: WP_015569912.1
• Coordinates: 1872701..1872943 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1597_RS08925	1869827..1870729	+	903	WP_014072386.1	formate dehydrogenase subunit beta	-
F1597_RS08930	1870726..1871361	+	636	WP_015569914.1	formate dehydrogenase cytochrome b556 subunit	-
F1597_RS08935	1871358..1872287	+	930	WP_006808712.1	formate dehydrogenase accessory protein FdhE	-
F1597_RS08940	1872327..1872698	-	372	WP_077266491.1	type II toxin-antitoxin system VapC family toxin	Toxin
F1597_RS08945	1872701..1872943	-	243	WP_015569912.1	ribbon-helix-helix domain-containing protein	Antitoxin
F1597_RS08950	1873142..1874062	+	921	WP_058687689.1	alpha/beta hydrolase	-
F1597_RS08955	1874071..1875012	-	942	WP_015569910.1	fatty acid biosynthesis protein FabY	-
F1597_RS08960	1875057..1875494	-	438	WP_015569909.1	D-tyrosyl-tRNA(Tyr) deacylase	-
F1597_RS08965	1875491..1876372	-	882	WP_003861949.1	virulence factor BrkB family protein	-
F1597_RS08970	1876366..1876965	-	600	WP_003861947.1	glucose-1-phosphatase	-
F1597_RS08975	1877084..1877884	-	801	WP_003861944.1	DeoR/GlpR family DNA-binding transcription regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13723.85 Da
• Isoelectric Point: 6.4882

>T139196 WP_077266491.1 NZ_CP043766:c1872698-1872327 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Nucleotide

• Length: 372 bp

>T139196 NZ_CP058571:175593-175700 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9440.72 Da
• Isoelectric Point: 4.4076

>AT139196 WP_015569912.1 NZ_CP043766:c1872943-1872701 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT139196 NZ_CP043766:c1872943-1872701 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAGCTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A6G4MTK3