Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1746825..1747429 Replicon chromosome
Accession NZ_CP043766
Organism Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag F1597_RS08370 Protein ID WP_071788668.1
Coordinates 1747244..1747429 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2G4ZRB5
Locus tag F1597_RS08365 Protein ID WP_023295606.1
Coordinates 1746825..1747229 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1597_RS08350 1742365..1743183 - 819 WP_033488031.1 helix-turn-helix domain-containing protein -
F1597_RS08355 1743409..1744809 + 1401 WP_033488030.1 MFS transporter -
F1597_RS08360 1744820..1746769 + 1950 WP_033488029.1 glycoside hydrolase family 127 protein -
F1597_RS08365 1746825..1747229 - 405 WP_023295606.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F1597_RS08370 1747244..1747429 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
F1597_RS08375 1747679..1749217 - 1539 WP_033488028.1 aldehyde dehydrogenase AldB -
F1597_RS08380 1749384..1750268 + 885 WP_003860164.1 ROK family protein -
F1597_RS08385 1750272..1752110 - 1839 WP_058686522.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T139195 WP_071788668.1 NZ_CP043766:c1747429-1747244 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T139195 NZ_CP058561:c3146339-3146082 [Vallitalea guaymasensis]
ATGAATAAAGTATTTTCTGATCTAGCATGGCAAGATTATACCTCTTGGTTAATTGAAGATAAAAAAATCCTAAAGCGTAT
AAACACTTTACTTAAAGATATTGATAGAAATGGAAACATAGGATTGGGTAAACCAGAGCCGCTTAGATACAATTTAAGAG
GTTATTGGAGTAGAAGAATTACAGATGAACATAGATTGATATATAAAATTGAAGATAATGAAATTTTGATTGTAGCATGT
AAAGGACATAATAACTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14954.71 Da        Isoelectric Point: 4.2329

>AT139195 WP_023295606.1 NZ_CP043766:c1747229-1746825 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEALPLPGSVEVHLENQPDDFTGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT139195 NZ_CP058561:c3146598-3146341 [Vallitalea guaymasensis]
ATGATAGCTACTAATTATTCAAATGCTAGACAAAAGTTCAAAGAATATTGTGATATTGCAAACGATGATTTTGAAACTAT
TATTGTGACACGCAAAAATGGCGGAAATGTTGTTATGATGAGTGAAACTGAATATAACAATCTATTAGAGAATATATTCG
TTATGGGTAATAAAACCAACTACGAACATATTATGAAATCCATAGACCAACTAAAAAAAGGTCATGCAAAAAAGAAAAAT
CTTATAGAGGTAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4ZRB5

References