Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 947367..948024 Replicon chromosome
Accession NZ_CP043766
Organism Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag F1597_RS04460 Protein ID WP_017382887.1
Coordinates 947367..947777 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag F1597_RS04465 Protein ID WP_003863437.1
Coordinates 947758..948024 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1597_RS04440 943365..945098 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
F1597_RS04445 945104..945817 - 714 WP_033487627.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F1597_RS04450 945846..946742 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
F1597_RS04455 946844..947365 + 522 WP_015571793.1 flavodoxin FldB -
F1597_RS04460 947367..947777 - 411 WP_017382887.1 protein YgfX Toxin
F1597_RS04465 947758..948024 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
F1597_RS04470 948319..949299 + 981 WP_017692714.1 tRNA-modifying protein YgfZ -
F1597_RS04475 949411..950071 - 661 Protein_858 hemolysin III family protein -
F1597_RS04480 950338..951069 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
F1597_RS04485 951186..952619 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T139193 WP_017382887.1 NZ_CP043766:c947777-947367 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T139193 NZ_CP043766:c947777-947367 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGGGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT139193 WP_003863437.1 NZ_CP043766:c948024-947758 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT139193 NZ_CP058557:c374284-374009 [Alkaliphilus sp. B6464]
ATGGCTGACTCAAAACGAATTATGATAAGCCTTCCTGACAGTCTTTTACAAGAGGTAGACAATATTGTTTCCATAGAAAA
GACAAATCGAAGTGAATTTATTCGTGAGGCGATGAAATTATATATACGGGAGAGAAATAAAATGGAATTACGGGAGCAGA
TGAAAAAAGGCTATCAAGAAATGGGACTAATCAATCTAGCATTGGCTGAATTGGGATTAAGCTTAGATATGTCATTGTTG
GAAACCTACGAAGCGCAGATGGCGGAGTGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References