Detailed information of TA system TA139190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1593368..1594003
• Replicon: chromosome
• Accession: NZ_CP043761
• Organism: Paenibacillus sp. 37

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: W4B4V0
• Locus tag: F0220_RS07005
• Protein ID: WP_024630714.1
• Coordinates: 1593653..1594003 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: W4B5R5
• Locus tag: F0220_RS07000
• Protein ID: WP_017690037.1
• Coordinates: 1593368..1593649 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0220_RS06990	1590329..1591525	+	1197	WP_149846370.1	DUF4367 domain-containing protein	-
F0220_RS06995	1591921..1593108	+	1188	WP_149846371.1	alanine racemase	-
F0220_RS07000	1593368..1593649	+	282	WP_017690037.1	ribbon-helix-helix protein, CopG family	Antitoxin
F0220_RS07005	1593653..1594003	+	351	WP_024630714.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
F0220_RS07010	1594238..1596427	+	2190	WP_149846372.1	alpha-galactosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12778.77 Da
• Isoelectric Point: 5.1184

>T139190 WP_024630714.1 NZ_CP043761:1593653-1594003 [Paenibacillus sp. 37]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTCIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMKLVNEALQISLGLIDF

Nucleotide

• Length: 351 bp

>T139190 NZ_CP058551:24955-25371 [Klebsiella pneumoniae]
GTGAACAAGATCTATATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGTGCCACCGGCC
CGAAGGCCTCGCCGCGCCACGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGACCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCCTCGCCGGAACGCCGATAGGCCCGAACGACACGGCGATCGC
CGGGCATGCCATTGCGGCCGGCGCCGTACTGGTGACAAATAATGTGCGGGAGTTTGAGCGGGTGCCGGATCTGGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10737.36 Da
• Isoelectric Point: 5.8649

>AT139190 WP_017690037.1 NZ_CP043761:1593368-1593649 [Paenibacillus sp. 37]
VANLQNTKRIMISLPDYLLQEVDGIVALENSNRSELIRQAMKLYLTERKKRYIRETMQRGYMEMAKINLTMASEAFHAEE
DADSTLDRLVSGV

Nucleotide

• Length: 282 bp

>AT139190 NZ_CP058551:24728-24958 [Klebsiella pneumoniae]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGGTCGTTCGCGCAGCTCG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGAAGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: W4B4V0

Antitoxin

• AlphaFold DB: W4B5R5