Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2230107..2231106 Replicon chromosome
Accession NZ_CP043727
Organism Yersinia canariae strain NCTC 14382

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag F0T03_RS10350 Protein ID WP_145556653.1
Coordinates 2230107..2230574 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag F0T03_RS10355 Protein ID WP_145556652.1
Coordinates 2230660..2231106 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0T03_RS10320 2226014..2226685 + 672 WP_159678200.1 phage shock protein PspA -
F0T03_RS10325 2226792..2227019 + 228 WP_005161022.1 envelope stress response membrane protein PspB -
F0T03_RS10330 2227019..2227393 + 375 WP_145556657.1 envelope stress response membrane protein PspC -
F0T03_RS10335 2227434..2227673 + 240 WP_159678202.1 phage shock protein PspD -
F0T03_RS10340 2227654..2229051 + 1398 WP_145556655.1 YcjX family protein -
F0T03_RS10345 2229048..2230112 + 1065 WP_159678204.1 YcjF family protein -
F0T03_RS10350 2230107..2230574 - 468 WP_145556653.1 RES family NAD+ phosphorylase Toxin
F0T03_RS10355 2230660..2231106 - 447 WP_145556652.1 DUF2384 domain-containing protein Antitoxin
F0T03_RS10360 2231427..2233004 + 1578 WP_159678206.1 transcriptional regulator TyrR -
F0T03_RS10365 2233101..2233604 - 504 WP_145556650.1 thiol peroxidase -
F0T03_RS10370 2233756..2234727 + 972 WP_145556649.1 L-Ala-D/L-Glu epimerase -
F0T03_RS10375 2234724..2235431 - 708 WP_145556648.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17513.83 Da        Isoelectric Point: 4.9038

>T139186 WP_145556653.1 NZ_CP043727:c2230574-2230107 [Yersinia canariae]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSHILLLQPQ
DWPADWRNDPAPATTMDIGTEWLESESSLGLLVPSTLVPSENNLLLNPRHKDFQTSLNSVKPLSFAFDSRLKSSS

Download         Length: 468 bp

>T139186 NZ_CP058549:56204-56620 [Klebsiella pneumoniae]
GTGAACAAAACTTACATGCTCGATACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTCATTAAGCGCCT
GGAGCAGGCGGTACTGCGCAATCAGCGTATCGTGATCTCCGCCATTACCTACGCGGAGCTGCGTTTCGGGGCCACCGGAC
CGAAGGCCTCACCGCGCCACATTGCGCTGGTTGACGCTTTCTGCGCCCGCCTCGATGCTGTCCTGCCTTGGGACCGCGCC
GCAGTGGACGCCACGACGGACATAAAAGTGGCGTTGCGGCTGGCCGGGATGCCTATTGGTCCGAATGACACGGCCATTGC
CGGGCACGCTATCGCCGCCGGCGCCATCCTAGTGACAAATAACACGCGGGAATTTGAACGGGTGCCGGGCCTGATGCTGG
AAGACTGGGTGAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16279.74 Da        Isoelectric Point: 9.2568

>AT139186 WP_145556652.1 NZ_CP043727:c2231106-2230660 [Yersinia canariae]
MRTFHPTPVSKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVELFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Download         Length: 447 bp

>AT139186 NZ_CP058549:55977-56207 [Klebsiella pneumoniae]
ATGCGCACAGTTTCAATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGACCTGGATTTTGAGGGCGTCAG
TGAGCTGGAGATCGTCCGAGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCGACATGGGGCTCGTTCGCGCAGCTCG
AAAAGGCCGACGCGGACTTTATGGCGGATCGCGAGGACGTTGTCAGCGATGAAGGACGATTTAATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References