Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1395165..1395799 Replicon chromosome
Accession NZ_CP043727
Organism Yersinia canariae strain NCTC 14382

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F0T03_RS06490 Protein ID WP_159677497.1
Coordinates 1395165..1395341 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F0T03_RS06495 Protein ID WP_159680737.1
Coordinates 1395392..1395799 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0T03_RS06470 1391760..1392143 + 384 WP_159677493.1 RusA family crossover junction endodeoxyribonuclease -
F0T03_RS06475 1392246..1392944 + 699 WP_159677494.1 phage antirepressor KilAC domain-containing protein -
F0T03_RS06480 1392941..1393942 + 1002 WP_159677495.1 DUF968 domain-containing protein -
F0T03_RS06485 1393968..1394621 + 654 WP_159677496.1 antitermination protein -
F0T03_RS06490 1395165..1395341 + 177 WP_159677497.1 type II toxin-antitoxin system HicA family toxin Toxin
F0T03_RS06495 1395392..1395799 + 408 WP_159680737.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F0T03_RS06500 1395943..1396332 + 390 WP_159677498.1 phage holin family protein -
F0T03_RS06505 1396325..1396606 + 282 WP_159677499.1 phage holin family protein -
F0T03_RS06510 1396603..1397229 + 627 WP_159677500.1 glycoside hydrolase family 19 protein -
F0T03_RS06515 1397226..1397558 + 333 WP_159677501.1 DUF2570 domain-containing protein -
F0T03_RS06520 1397829..1398029 - 201 WP_159677502.1 hypothetical protein -
F0T03_RS06525 1398232..1398876 + 645 WP_159677503.1 hypothetical protein -
F0T03_RS06530 1399142..1399708 + 567 WP_159677504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1378119..1424239 46120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(79-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6793.90 Da        Isoelectric Point: 10.9526

>T139177 WP_159677497.1 NZ_CP043727:1395165-1395341 [Yersinia canariae]
VKQSEFRRWLEAQGVEFKNGTNHLKLYYQGRQSVMPRHPGKEIGETLRKAIIKQLGIK

Download         Length: 177 bp

>T139177 NZ_CP058548:1978646-1978987 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGACCGTTGCAGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAGCAACACTATGGCCTGACGCTGAACGACACACCATTCAGTGATGTAACCGTTATTCAGGAGCATATCA
ACGCCGGTATTACGCTGGCTGATGCCGTTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAAGTTTT
AACTGTCAGGAGCAATCACCTTATATTCGGGCGGTAGATATTTTACGGGCAAGACAGGCAACTGGCCTGTTGCGACAAAG
CCGTAACAACGCAGTACGGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14896.10 Da        Isoelectric Point: 4.3423

>AT139177 WP_159680737.1 NZ_CP043727:1395392-1395799 [Yersinia canariae]
MRYPVKLQKEGDGYFVSFPDIPEALTQGDTREEALEMARDALVTAFEFYFEDNRPVPLPSGLGDDFVSVPASVWAKVLLL
NAMLETGITNAELARRMGLKPQEVQRIVTLGHNTKIDTIEAALAALGKCLELSIE

Download         Length: 408 bp

>AT139177 NZ_CP058548:1978307-1978624 [Klebsiella pneumoniae]
ATGAGCAACACCACATGGGGCCTGCAGCGGGATATTACACCGCGCATGGGGGCACGTCTGGTACAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCAGTAAGTTTAGTGATGCCGAATGCCAGAAGTTGGATATCGCATTTCCGC
ATTTTATCAGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGGCATGCCCATTGCGTCACCCTGTACCAC
AACGGTTATACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCTGTTTATCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References